Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2154420..2154946 | Replicon | chromosome |
| Accession | NC_013361 | ||
| Organism | Escherichia coli O26:H11 str. 11368 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | ECO26_RS11490 | Protein ID | WP_000323025.1 |
| Coordinates | 2154420..2154707 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | ECO26_RS11495 | Protein ID | WP_000534858.1 |
| Coordinates | 2154707..2154946 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ECO26_RS11450 | 2149444..2149659 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| ECO26_RS11455 | 2150413..2150628 | - | 216 | WP_000066483.1 | cold shock-like protein CspB | - |
| ECO26_RS11460 | 2150929..2151141 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| ECO26_RS33975 | 2151196..2151285 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| ECO26_RS11465 | 2151563..2152315 | - | 753 | WP_001047133.1 | antitermination protein | - |
| ECO26_RS11470 | 2152329..2153378 | - | 1050 | WP_001265198.1 | DUF968 domain-containing protein | - |
| ECO26_RS11475 | 2153380..2153658 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| ECO26_RS11480 | 2153725..2153976 | - | 252 | WP_000980994.1 | hypothetical protein | - |
| ECO26_RS11485 | 2154193..2154348 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| ECO26_RS11490 | 2154420..2154707 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| ECO26_RS11495 | 2154707..2154946 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| ECO26_RS31935 | 2154971..2155276 | + | 306 | WP_001326990.1 | hypothetical protein | - |
| ECO26_RS11500 | 2155479..2155811 | + | 333 | WP_001317460.1 | FlxA-like family protein | - |
| ECO26_RS11505 | 2156248..2157588 | - | 1341 | WP_000589012.1 | ISNCY family transposase | - |
| ECO26_RS11510 | 2157622..2158041 | - | 420 | WP_001151195.1 | DUF977 family protein | - |
| ECO26_RS11515 | 2158082..2159047 | - | 966 | WP_000054507.1 | hypothetical protein | - |
| ECO26_RS11520 | 2159028..2159549 | - | 522 | WP_000705349.1 | hypothetical protein | - |
| ECO26_RS11525 | 2159533..2159760 | - | 228 | WP_000476993.1 | transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | nleC | 2119094..2219001 | 99907 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T24318 WP_000323025.1 NC_013361:c2154707-2154420 [Escherichia coli O26:H11 str. 11368]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T24318 NC_013361:c2154707-2154420 [Escherichia coli O26:H11 str. 11368]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT24318 WP_000534858.1 NC_013361:c2154946-2154707 [Escherichia coli O26:H11 str. 11368]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT24318 NC_013361:c2154946-2154707 [Escherichia coli O26:H11 str. 11368]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|