Detailed information of TA system TA243179

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 3648244..3648803
• Replicon: chromosome
• Accession: NZ_CP096583
• Organism: Rhodococcus pyridinivorans strain PE41

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: M1C57_RS16775
• Protein ID: WP_282706450.1
• Coordinates: 3648558..3648803 (+)
• Length: 82 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: M1C57_RS16770
• Protein ID: WP_024102980.1
• Coordinates: 3648244..3648528 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1C57_RS16745 (M1C57_16745)	3643447..3644073	+	627	WP_231911981.1	TetR/AcrR family transcriptional regulator	-
M1C57_RS16750 (M1C57_16750)	3644070..3644498	+	429	WP_024102975.1	HIT family protein	-
M1C57_RS16755 (M1C57_16755)	3644503..3646104	+	1602	WP_024102976.1	L-lactate permease	-
M1C57_RS16760 (M1C57_16760)	3646181..3647209	+	1029	WP_064255975.1	Dyp-type peroxidase	-
M1C57_RS16765 (M1C57_16765)	3647206..3648024	+	819	WP_006551857.1	family 1 encapsulin nanocompartment shell protein	-
M1C57_RS16770 (M1C57_16770)	3648244..3648528	+	285	WP_024102980.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
M1C57_RS16775 (M1C57_16775)	3648558..3648803	+	246	WP_282706450.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
M1C57_RS16780 (M1C57_16780)	3648860..3649171	-	312	WP_138841658.1	hypothetical protein	-
M1C57_RS16785 (M1C57_16785)	3649230..3649976	-	747	WP_248689538.1	cutinase family protein	-
M1C57_RS16790 (M1C57_16790)	3650126..3650788	-	663	WP_094979476.1	alpha-ketoglutarate-dependent dioxygenase AlkB	-
M1C57_RS16795 (M1C57_16795)	3650909..3651739	+	831	WP_248689539.1	SDR family oxidoreductase	-
M1C57_RS16800 (M1C57_16800)	3651784..3652755	+	972	WP_006551850.1	phosphotriesterase	-
M1C57_RS16805 (M1C57_16805)	3652792..3653511	-	720	WP_041803971.1	2OG-Fe(II) oxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (29-80)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8999.38 Da
• Isoelectric Point: 10.3368

>T243179 WP_282706450.1 NZ_CP096583:3648558-3648803 [Rhodococcus pyridinivorans]
MARSAVRAMARSLPEKVATAVYEFVTGPLLENPKRVGKPLNPPLAPAYSARRGEYRVLYLIDDANRTVEVTAISHRADAY
R

Nucleotide

• Length: 246 bp

>T243179 NZ_OW970413:835138-835548 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10494.56 Da
• Isoelectric Point: 4.2336

>AT243179 WP_024102980.1 NZ_CP096583:3648244-3648528 [Rhodococcus pyridinivorans]
MTTLPVADARAQLSRLVDEAERTHERFEITRNGHRAAVLLGADDYDAMQETIAVLSDTDLLRAHVEGRTEVESGDVVDVQ
ELTQLMRDARSSEE

Nucleotide

• Length: 285 bp

>AT243179 NZ_OW970413:834891-835157 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA