Detailed information of TA system TA243178

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 2795578..2796077
• Replicon: chromosome
• Accession: NZ_CP096583
• Organism: Rhodococcus pyridinivorans strain PE41

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: M1C57_RS12750
• Protein ID: WP_230810696.1
• Coordinates: 2795578..2795832 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: H0JMW3
• Locus tag: M1C57_RS12755
• Protein ID: WP_006550855.1
• Coordinates: 2795829..2796077 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1C57_RS12720 (M1C57_12720)	2791012..2792181	-	1170	WP_248689233.1	acyl-CoA dehydrogenase family protein	-
M1C57_RS12725 (M1C57_12725)	2792284..2792910	+	627	WP_006550849.1	TetR family transcriptional regulator	-
M1C57_RS12730 (M1C57_12730)	2793068..2793280	-	213	WP_248689234.1	hypothetical protein	-
M1C57_RS12735 (M1C57_12735)	2793287..2793475	-	189	WP_248689235.1	hypothetical protein	-
M1C57_RS12740 (M1C57_12740)	2793843..2794799	-	957	WP_248689236.1	ERCC4 domain-containing protein	-
M1C57_RS12745 (M1C57_12745)	2794956..2795477	+	522	WP_248689237.1	hypothetical protein	-
M1C57_RS12750 (M1C57_12750)	2795578..2795832	-	255	WP_230810696.1	Txe/YoeB family addiction module toxin	Toxin
M1C57_RS12755 (M1C57_12755)	2795829..2796077	-	249	WP_006550855.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
M1C57_RS12760 (M1C57_12760)	2796302..2796442	+	141	Protein_2533	pirin-like C-terminal cupin domain-containing protein	-
M1C57_RS12765 (M1C57_12765)	2796909..2797703	+	795	WP_006550857.1	LLM class F420-dependent oxidoreductase	-
M1C57_RS12770 (M1C57_12770)	2797764..2799014	+	1251	WP_138845195.1	alpha/beta fold hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-70)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10063.40 Da
• Isoelectric Point: 8.0410

>T243178 WP_230810696.1 NZ_CP096583:c2795832-2795578 [Rhodococcus pyridinivorans]
VNITFTDEAWDDYQFWISTDRKQLKRVNELVRDCQRDPYSGIGKPERLRHALSGLWSRRIDKEHRLVYEVIDGALVIIAA
RYHY

Nucleotide

• Length: 255 bp

>T243178 NZ_OW970413:357717-358064 [Klebsiella pneumoniae]
ATGTGGGATGTGGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATAAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9290.59 Da
• Isoelectric Point: 5.8315

>AT243178 WP_006550855.1 NZ_CP096583:c2796077-2795829 [Rhodococcus pyridinivorans]
MAAITATEARKNFFPLLEQVNKDHTPVEIVSKRGNAVLMSKDDYDAMLETSYLMQSPANARRLLASMQRARGGEYTEREL
IE

Nucleotide

• Length: 249 bp

>AT243178 NZ_OW970413:358064-358363 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAAAGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Structures

Antitoxin

• AlphaFold DB: H0JMW3