Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 2795578..2796077 Replicon chromosome
Accession NZ_CP096583
Organism Rhodococcus pyridinivorans strain PE41

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag M1C57_RS12750 Protein ID WP_230810696.1
Coordinates 2795578..2795832 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID H0JMW3
Locus tag M1C57_RS12755 Protein ID WP_006550855.1
Coordinates 2795829..2796077 (-) Length 83 a.a.

Genomic Context

M1C57_RS12725M1C57_RS12745M1C57_RS12760M1C57_RS12765M1C57_RS12770M1C57_RS12720M1C57_RS12730M1C57_RS12735M1C57_RS12740M1C57_RS12750M1C57_RS12755
Location: 2792284..2792910 (627 bp)
Type: Others
Protein ID: WP_006550849.1
Location: 2794956..2795477 (522 bp)
Type: Others
Protein ID: WP_248689237.1
Location: 2796302..2796442 (141 bp)
Type: Others
Protein ID: Protein_2533
Location: 2796909..2797703 (795 bp)
Type: Others
Protein ID: WP_006550857.1
Location: 2797764..2799014 (1251 bp)
Type: Others
Protein ID: WP_138845195.1
Location: 2791012..2792181 (1170 bp)
Type: Others
Protein ID: WP_248689233.1
Location: 2793068..2793280 (213 bp)
Type: Others
Protein ID: WP_248689234.1
Location: 2793287..2793475 (189 bp)
Type: Others
Protein ID: WP_248689235.1
Location: 2793843..2794799 (957 bp)
Type: Others
Protein ID: WP_248689236.1
Location: 2795578..2795832 (255 bp)
Type: Toxin
Protein ID: WP_230810696.1
Location: 2795829..2796077 (249 bp)
Type: Antitoxin
Protein ID: WP_006550855.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
M1C57_RS12720 (M1C57_12720)2791012..2792181-1170WP_248689233.1acyl-CoA dehydrogenase family protein-
M1C57_RS12725 (M1C57_12725)2792284..2792910+627WP_006550849.1TetR family transcriptional regulator-
M1C57_RS12730 (M1C57_12730)2793068..2793280-213WP_248689234.1hypothetical protein-
M1C57_RS12735 (M1C57_12735)2793287..2793475-189WP_248689235.1hypothetical protein-
M1C57_RS12740 (M1C57_12740)2793843..2794799-957WP_248689236.1ERCC4 domain-containing protein-
M1C57_RS12745 (M1C57_12745)2794956..2795477+522WP_248689237.1hypothetical protein-
M1C57_RS12750 (M1C57_12750)2795578..2795832-255WP_230810696.1Txe/YoeB family addiction module toxinToxin
M1C57_RS12755 (M1C57_12755)2795829..2796077-249WP_006550855.1type II toxin-antitoxin system prevent-host-death family antitoxinAntitoxin
M1C57_RS12760 (M1C57_12760)2796302..2796442+141Protein_2533pirin-like C-terminal cupin domain-containing protein-
M1C57_RS12765 (M1C57_12765)2796909..2797703+795WP_006550857.1LLM class F420-dependent oxidoreductase-
M1C57_RS12770 (M1C57_12770)2797764..2799014+1251WP_138845195.1alpha/beta fold hydrolase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-70)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10063.40 Da        Isoelectric Point: 8.0410

>T243178 WP_230810696.1 NZ_CP096583:c2795832-2795578 [Rhodococcus pyridinivorans]
VNITFTDEAWDDYQFWISTDRKQLKRVNELVRDCQRDPYSGIGKPERLRHALSGLWSRRIDKEHRLVYEVIDGALVIIAA
RYHY

Download         Length: 255 bp

>T243178 NZ_OW970413:357717-358064 [Klebsiella pneumoniae]
ATGTGGGATGTGGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATAAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9290.59 Da        Isoelectric Point: 5.8315

>AT243178 WP_006550855.1 NZ_CP096583:c2796077-2795829 [Rhodococcus pyridinivorans]
MAAITATEARKNFFPLLEQVNKDHTPVEIVSKRGNAVLMSKDDYDAMLETSYLMQSPANARRLLASMQRARGGEYTEREL
IE

Download         Length: 249 bp

>AT243178 NZ_OW970413:358064-358363 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAAAGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBH0JMW3

References