Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2577496..2578037 Replicon chromosome
Accession NZ_CP096583
Organism Rhodococcus pyridinivorans strain PE41

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag M1C57_RS11625 Protein ID WP_138845823.1
Coordinates 2577496..2577795 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag M1C57_RS11630 Protein ID WP_138844995.1
Coordinates 2577795..2578037 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1C57_RS11590 (M1C57_11590) 2573161..2573976 + 816 WP_248689164.1 SDR family oxidoreductase -
M1C57_RS11595 (M1C57_11595) 2574134..2574874 + 741 WP_138844993.1 FadR/GntR family transcriptional regulator -
M1C57_RS11600 (M1C57_11600) 2575067..2575204 + 138 WP_248689165.1 hypothetical protein -
M1C57_RS11605 (M1C57_11605) 2575275..2575433 - 159 WP_248689166.1 hypothetical protein -
M1C57_RS11610 (M1C57_11610) 2575594..2576469 - 876 WP_228044770.1 hypothetical protein -
M1C57_RS11615 (M1C57_11615) 2576498..2576728 + 231 WP_228044773.1 hypothetical protein -
M1C57_RS11620 (M1C57_11620) 2576768..2577118 + 351 Protein_2305 dihydrofolate reductase family protein -
M1C57_RS11625 (M1C57_11625) 2577496..2577795 - 300 WP_138845823.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
M1C57_RS11630 (M1C57_11630) 2577795..2578037 - 243 WP_138844995.1 YlcI/YnfO family protein Antitoxin
M1C57_RS11635 (M1C57_11635) 2578481..2579395 + 915 WP_248689167.1 LLM class flavin-dependent oxidoreductase -
M1C57_RS11640 (M1C57_11640) 2579996..2580547 - 552 WP_138844999.1 TetR/AcrR family transcriptional regulator -
M1C57_RS11645 (M1C57_11645) 2580704..2581237 + 534 WP_102799258.1 thioesterase family protein -
M1C57_RS11650 (M1C57_11650) 2581729..2582532 + 804 WP_248689168.1 enoyl-CoA hydratase-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 10529.25 Da        Isoelectric Point: 8.0583

>T243177 WP_138845823.1 NZ_CP096583:c2577795-2577496 [Rhodococcus pyridinivorans]
MRPIHAAKLDKTRPVLVLTRELVRPHLGRVTVAPITGTVRGLSTEVPVGPANGLEKDSVVSCDNIVTIPVSALGRSLGFF
FPAQEAALSEAIRAAFDLE

Download         Length: 300 bp

>T243177 NZ_OW970413:331748-332116 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGACAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9031.14 Da        Isoelectric Point: 4.9060

>AT243177 WP_138844995.1 NZ_CP096583:c2578037-2577795 [Rhodococcus pyridinivorans]
MSTQIAVRLPDEIVAFVDEEVREHRAPSRAALVLRALERERRRRIAARDVEILSRARGEADPDEFDGLARYAAGLSSDLE

Download         Length: 243 bp

>AT243177 NZ_OW970413:331530-331751 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References