Detailed information of TA system TA243176

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 452300..453252
• Replicon: chromosome
• Accession: NZ_CP096583
• Organism: Rhodococcus pyridinivorans strain PE41

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: M1C57_RS02005
• Protein ID: WP_248690194.1
• Coordinates: 452300..452869 (-)
• Length: 190 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: M1C57_RS02010
• Protein ID: WP_248690195.1
• Coordinates: 452866..453252 (-)
• Length: 129 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1C57_RS02005 (M1C57_02005)	452300..452869	-	570	WP_248690194.1	zeta toxin family protein	Toxin
M1C57_RS02010 (M1C57_02010)	452866..453252	-	387	WP_248690195.1	ParD-like family protein	Antitoxin
M1C57_RS02015 (M1C57_02015)	453460..454530	+	1071	WP_197481790.1	methyltransferase domain-containing protein	-
M1C57_RS02020 (M1C57_02020)	454600..454965	+	366	WP_024101068.1	HNH endonuclease	-
M1C57_RS02025 (M1C57_02025)	454982..455527	-	546	WP_248690196.1	hypothetical protein	-
M1C57_RS02030 (M1C57_02030)	456630..457562	-	933	WP_248690197.1	TAXI family TRAP transporter solute-binding subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (5-136)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (7-102)

Sequences

Toxin

Protein

• Length: 190 a.a.
• Molecular weight: 20494.62 Da
• Isoelectric Point: 10.3998

>T243176 WP_248690194.1 NZ_CP096583:c452869-452300 [Rhodococcus pyridinivorans]
MRRLDLIVGPNGSGKSTFVELSLAPLLPRSVFVNADVIAQQRWPDRAEEMSYEAAQLAAAARDRLLRQGRSFIAETVFSH
PSKLELIDRAHEVGFTVVLHVMLVPEAMSVLRVQHRVASGGHAVPEDKIRARYRRLWPLVAEAIGRADQASVYDTASGTP
VVVARFAGGVPVGAVRWPGWAPAALTGLG

Nucleotide

• Length: 570 bp

>T243176 NZ_OW970376:17688-18104 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGAATCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGACCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAATAA

Antitoxin

Protein

• Length: 129 a.a.
• Molecular weight: 14024.47 Da
• Isoelectric Point: 4.7096

>AT243176 WP_248690195.1 NZ_CP096583:c453252-452866 [Rhodococcus pyridinivorans]
MTSSTDKVTRFDAELVDSAIAEGGRQNRTGRQQLEYWARIGRAMTAHETASLHRVHEALAGTRELSELTAAEGRLFDAEI
DARLADGLARTDYAEVLAARGVSTVVLDDEGRLVEQRPDGSRRVLDDA

Nucleotide

• Length: 387 bp

>AT243176 NZ_OW970376:17461-17691 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA