Detailed information of TA system TA243175

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 3447726..3448379
• Replicon: chromosome
• Accession: NZ_CP096575
• Organism: Acinetobacter baumannii strain F46

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: M1L34_RS16515
• Protein ID: WP_000607077.1
• Coordinates: 3447726..3448115 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: M1L34_RS16520
• Protein ID: WP_001288210.1
• Coordinates: 3448122..3448379 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1L34_RS16500 (M1L34_16500)	3442844..3445039	-	2196	WP_001158906.1	TRAP transporter large permease subunit	-
M1L34_RS16505 (M1L34_16505)	3445227..3445793	-	567	WP_000651538.1	rhombosortase	-
M1L34_RS16510 (M1L34_16510)	3445871..3446956	-	1086	WP_000049106.1	hypothetical protein	-
M1L34_RS16515 (M1L34_16515)	3447726..3448115	-	390	WP_000607077.1	membrane protein	Toxin
M1L34_RS16520 (M1L34_16520)	3448122..3448379	-	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
M1L34_RS16525 (M1L34_16525)	3448567..3449739	+	1173	WP_001190542.1	acyl-CoA dehydrogenase family protein	-
M1L34_RS16530 (M1L34_16530)	3449788..3451278	-	1491	WP_000415125.1	NAD(P)/FAD-dependent oxidoreductase	-
M1L34_RS16535 (M1L34_16535)	3451460..3451837	-	378	WP_001216380.1	50S ribosomal protein L17	-
M1L34_RS16540 (M1L34_16540)	3451856..3452863	-	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15552.88 Da
• Isoelectric Point: 10.4313

>T243175 WP_000607077.1 NZ_CP096575:c3448115-3447726 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAVLFYQLMPLLWWLVVISLLFISFIFFLKRPQLAQIAYLDKKLWSLAYKSQNTV
SRVKILKIIDCQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T243175 NZ_OW970375:116686-116991 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGACAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGGCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT243175 WP_001288210.1 NZ_CP096575:c3448379-3448122 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT243175 NZ_OW970375:116466-116684 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7