Detailed information of TA system TA243174

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2353496..2354175
• Replicon: chromosome
• Accession: NZ_CP096575
• Organism: Acinetobacter baumannii strain F46

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: M1L34_RS11395
• Protein ID: WP_000838146.1
• Coordinates: 2353993..2354175 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: M1L34_RS11390
• Protein ID: WP_000966688.1
• Coordinates: 2353496..2353900 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1L34_RS11380 (M1L34_11380)	2352428..2352690	-	263	Protein_2228	hypothetical protein	-
M1L34_RS11385 (M1L34_11385)	2352692..2353370	-	679	Protein_2229	hypothetical protein	-
M1L34_RS11390 (M1L34_11390)	2353496..2353900	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
M1L34_RS11395 (M1L34_11395)	2353993..2354175	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
M1L34_RS11400 (M1L34_11400)	2354501..2355016	-	516	WP_024616020.1	hypothetical protein	-
M1L34_RS11405 (M1L34_11405)	2355087..2356004	-	918	WP_000094253.1	phage tail tube protein	-
M1L34_RS11410 (M1L34_11410)	2356057..2357412	-	1356	WP_000002415.1	hypothetical protein	-
M1L34_RS11415 (M1L34_11415)	2357412..2357765	-	354	WP_000064593.1	hypothetical protein	-
M1L34_RS11420 (M1L34_11420)	2357862..2358382	-	521	Protein_2236	SH3 domain-containing protein	-
M1L34_RS11425 (M1L34_11425)	2358491..2358709	-	219	WP_001277696.1	hypothetical protein	-
M1L34_RS11430 (M1L34_11430)	2358711..2359154	-	444	WP_002016455.1	phage tail terminator-like protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	plc / pgaD / pgaC / pgaB / csuE / csuD / csuC / csuB / csuA / csuA/B	2180399..2586517	406118

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T243174 WP_000838146.1 NZ_CP096575:c2354175-2353993 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T243174 NZ_OW970375:c105317-105006 [Klebsiella pneumoniae]
ATGCACATTGTATCGAGAGCACCTTTCGATACAGCCACCAGGCAATTCCCCAATCAGGCAGCGGCACTAGACGACGTATA
CCGGACTTTGAAGAGAGAGAACTACACTTCACCGGACGAAATGAAAAAACGATTTGCCTCGCTGGACAGAATGAAATATC
GGGAGAAGTGGTGGGTGATCGATGTTGGCGGTGGGAATTTAAGGGTGATGTTTTTTGCTGATTTTGAACGTGGGAAAATC
TTTATAAAGCACATAACCACACACGCCGAATACGACAAGCTGACAGATTTTTACCGGAGAACTAAAGAATGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT243174 WP_000966688.1 NZ_CP096575:c2353900-2353496 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT243174 NZ_OW970375:c105009-104590 [Klebsiella pneumoniae]
ATGATGTACACCGATGCTATCCAGGCGGCAAACAGCCTGGTTAGCATTGTCCCCCTCCTGGGGGGCAATGCCTCTCGCAA
GGACTATGAAGACGCGCTGACGCTGGTTGAATACCTGGTTGAACACGAGCCAGATCATCCGCTGGTGGACATGCTGGTTG
CGAAAATTGCCCAGTATGAAGATGAGGCGGAAGAGTTCGCAGAGTTCAACGACCGTATTGCAGCGTTACCAAGTGGCGTG
GCCCTGCTGCGTGTCCTGATGGACCAGCACAAACTGACTCAGAGTGATTTTGAGGAAGAGATTGGTAAGAAATCGCTGGT
GAGCCGCATCCTTAACGGGACTCGCTCACTAACACTAGATCACATGAAAGCACTTGCGCGGCGCTTCAACATTCCGCCCA
GCTCATTCATGGACGCGTAA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6