Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 253698..254281 Replicon chromosome
Accession NZ_CP096574
Organism Geomonas paludis strain RG22

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag M1B72_RS01105 Protein ID WP_183350887.1
Coordinates 253698..254042 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag M1B72_RS01110 Protein ID WP_183350889.1
Coordinates 254039..254281 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1B72_RS01080 (M1B72_01080) 249309..249920 - 612 WP_246405040.1 hypothetical protein -
M1B72_RS01085 (M1B72_01085) 250038..250751 - 714 WP_183350882.1 DUF3108 domain-containing protein -
M1B72_RS01090 (M1B72_01090) 250795..250977 - 183 WP_183350883.1 hypothetical protein -
M1B72_RS01095 (M1B72_01095) 251336..252898 - 1563 WP_183350884.1 acetyl-CoA hydrolase/transferase C-terminal domain-containing protein -
M1B72_RS01100 (M1B72_01100) 253091..253684 + 594 WP_183350885.1 TetR/AcrR family transcriptional regulator -
M1B72_RS01105 (M1B72_01105) 253698..254042 - 345 WP_183350887.1 endoribonuclease MazF Toxin
M1B72_RS01110 (M1B72_01110) 254039..254281 - 243 WP_183350889.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
M1B72_RS01115 (M1B72_01115) 254360..255289 - 930 WP_183350891.1 cation diffusion facilitator family transporter -
M1B72_RS01120 (M1B72_01120) 255462..257102 - 1641 WP_183350893.1 methyl-accepting chemotaxis protein -
M1B72_RS01125 (M1B72_01125) 257497..257715 - 219 WP_183350895.1 hypothetical protein -
M1B72_RS01130 (M1B72_01130) 257843..258715 - 873 WP_183350897.1 DMT family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-113)

Antitoxin

SpoVT-AbrB domain

(6-46)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 12506.46 Da        Isoelectric Point: 9.6276

>T243169 WP_183350887.1 NZ_CP096574:c254042-253698 [Geomonas paludis]
MTAAGYVPDRGEVVWLDFDPQAGHEHAGRRPAFVLSPRNYNKKTSLMLCCPITSQVKGYPFEVAVAGVTTVRGVILADQV
KSLDWQVRRAEKGGRASRGVLEEVILKVRAILEG

Download         Length: 345 bp

>T243169 NZ_OW970374:c3960425-3960108 [Klebsiella pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8624.03 Da        Isoelectric Point: 5.0656

>AT243169 WP_183350889.1 NZ_CP096574:c254281-254039 [Geomonas paludis]
MVAKAQKWGNSLAVRLPKSIAAECGIEAESPVEITRQEGYIVIKPIVNKVLSLDALLDGINEENLHAEVSCGKPVGRELL

Download         Length: 243 bp

>AT243169 NZ_OW970374:c3960115-3959828 [Klebsiella pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACAGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References