Detailed information of TA system TA243168

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 4234661..4235166
• Replicon: chromosome
• Accession: NZ_CP096570
• Organism: Xanthomonas translucens pv. undulosa strain Xtu-UPB513

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MZO50_RS18750
• Protein ID: WP_058358982.1
• Coordinates: 4234909..4235166 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1C3TRJ9
• Locus tag: MZO50_RS18745
• Protein ID: WP_003468816.1
• Coordinates: 4234661..4234912 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MZO50_RS18715 (MZO50_18720)	4230522..4230812	-	291	WP_003468827.1	hypothetical protein	-
MZO50_RS18720 (MZO50_18725)	4231147..4231422	+	276	WP_003468826.1	hypothetical protein	-
MZO50_RS18725 (MZO50_18730)	4231590..4232279	-	690	WP_196479346.1	hypothetical protein	-
MZO50_RS18730 (MZO50_18735)	4232448..4232897	-	450	WP_003468823.1	nuclear transport factor 2 family protein	-
MZO50_RS18735 (MZO50_18740)	4233021..4233743	+	723	WP_248645942.1	helix-turn-helix transcriptional regulator	-
MZO50_RS18740 (MZO50_18745)	4233740..4234504	-	765	WP_068873280.1	DNA-formamidopyrimidine glycosylase family protein	-
MZO50_RS18745 (MZO50_18750)	4234661..4234912	+	252	WP_003468816.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
MZO50_RS18750 (MZO50_18755)	4234909..4235166	+	258	WP_058358982.1	Txe/YoeB family addiction module toxin	Toxin
MZO50_RS18755 (MZO50_18760)	4235525..4236169	-	645	WP_081318762.1	DUF4145 domain-containing protein	-
MZO50_RS18760 (MZO50_18765)	4236453..4237013	-	561	WP_141696960.1	hypothetical protein	-
MZO50_RS18770 (MZO50_18775)	4237360..4237713	-	354	WP_003468813.1	PilZ domain-containing protein	-
MZO50_RS18775 (MZO50_18780)	4237710..4238687	-	978	WP_003468812.1	DNA polymerase III subunit delta'	-
MZO50_RS18780 (MZO50_18785)	4238684..4239352	-	669	WP_003468811.1	dTMP kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10181.66 Da
• Isoelectric Point: 9.3936

>T243168 WP_058358982.1 NZ_CP096570:4234909-4235166 [Xanthomonas translucens pv. undulosa]
VTLQFSDNAWEDDLYWQQTDKKMLKRVNDLIKAIQRDPFQGVGKPEPLRHALAGYWSRRINEEHRIVYRVEAGILLIAQV
RYHYL

Nucleotide

• Length: 258 bp

>T243168 NZ_OW970374:c2789097-2787775 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGAGGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTTTCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCGCCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCTACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9281.56 Da
• Isoelectric Point: 5.1186

>AT243168 WP_003468816.1 NZ_CP096570:4234661-4234912 [Xanthomonas translucens pv. undulosa]
MDTITYSAARAALADTMERVVNNHEPVIITRSREQSVVMLSLEDYKAMEETAYLLRSPKSAQRLLESIAQLEAGRGKARD
LAE

Nucleotide

• Length: 252 bp

>AT243168 NZ_OW970374:c2789363-2789097 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A1C3TRJ9