Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicA
Location 1142706..1143118 Replicon chromosome
Accession NZ_CP096570
Organism Xanthomonas translucens pv. undulosa strain Xtu-UPB513

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag MZO50_RS05380 Protein ID WP_248646053.1
Coordinates 1142706..1142900 (+) Length 65 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MZO50_RS05385 Protein ID WP_248646054.1
Coordinates 1142906..1143118 (+) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MZO50_RS05370 (MZO50_05360) 1137727..1139667 - 1941 WP_058362363.1 SpoIIE family protein phosphatase -
MZO50_RS05375 (MZO50_05365) 1139903..1142593 + 2691 WP_038237130.1 pyruvate dehydrogenase (acetyl-transferring), homodimeric type -
MZO50_RS05380 (MZO50_05370) 1142706..1142900 + 195 WP_248646053.1 type II toxin-antitoxin system HicA family toxin Toxin
MZO50_RS05385 (MZO50_05375) 1142906..1143118 + 213 WP_248646054.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MZO50_RS05390 (MZO50_05380) 1143349..1143984 + 636 WP_081324067.1 NYN domain-containing protein -
MZO50_RS05395 (MZO50_05385) 1144029..1144508 - 480 WP_081324064.1 DNA mismatch endonuclease Vsr -
MZO50_RS05400 (MZO50_05390) 1144508..1146166 - 1659 WP_248646055.1 DUF2357 domain-containing protein -
MZO50_RS05405 (MZO50_05395) 1146169..1147845 - 1677 WP_068873386.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-62)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-62)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7060.07 Da        Isoelectric Point: 10.8749

>T243167 WP_248646053.1 NZ_CP096570:1142706-1142900 [Xanthomonas translucens pv. undulosa]
MPPTIRDVLQQLRDAGWQQVGQTGSYRQFKHPVYPGRVTVTGKPSDDVAPGTLNSILKQAGLKR

Download         Length: 195 bp

>T243167 NZ_OW970374:2069243-2069345 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7479.39 Da        Isoelectric Point: 3.8074

>AT243167 WP_248646054.1 NZ_CP096570:1142906-1143118 [Xanthomonas translucens pv. undulosa]
MRYAVVIEQAGNNYSAYVPDLPGCVATGETTAEVEGLIREAIELHLAGMREDGEVIPLPSSQVEYVDVAA

Download         Length: 213 bp

>AT243167 NZ_OW970374:c2069352-2069207 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References