Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_19(antitoxin) |
| Location | 357422..358210 | Replicon | chromosome |
| Accession | NZ_CP096540 | ||
| Organism | Staphylococcus aureus strain RIVM_M044329 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A2I7Y5B3 |
| Locus tag | M1F45_RS01585 | Protein ID | WP_000525004.1 |
| Coordinates | 357422..357883 (-) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0E7YIA0 |
| Locus tag | M1F45_RS01590 | Protein ID | WP_000333630.1 |
| Coordinates | 357896..358210 (-) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M1F45_RS01560 (M1F45_01555) | 352474..354408 | + | 1935 | Protein_309 | YSIRK domain-containing triacylglycerol lipase Lip2/Geh | - |
| M1F45_RS01565 (M1F45_01560) | 354502..355707 | - | 1206 | WP_031795352.1 | tyrosine-type recombinase/integrase | - |
| M1F45_RS01570 (M1F45_01565) | 355833..356447 | + | 615 | WP_000191466.1 | hypothetical protein | - |
| M1F45_RS01575 (M1F45_01570) | 356444..356590 | - | 147 | WP_074370993.1 | hypothetical protein | - |
| M1F45_RS01580 (M1F45_01575) | 356820..357404 | - | 585 | WP_000825948.1 | hypothetical protein | - |
| M1F45_RS01585 (M1F45_01580) | 357422..357883 | - | 462 | WP_000525004.1 | hypothetical protein | Toxin |
| M1F45_RS01590 (M1F45_01585) | 357896..358210 | - | 315 | WP_000333630.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| M1F45_RS01595 (M1F45_01590) | 358362..358598 | + | 237 | WP_001121027.1 | helix-turn-helix transcriptional regulator | - |
| M1F45_RS01600 (M1F45_01595) | 358612..359388 | + | 777 | WP_001148544.1 | Rha family transcriptional regulator | - |
| M1F45_RS01605 (M1F45_01600) | 359417..359560 | + | 144 | WP_031797335.1 | hypothetical protein | - |
| M1F45_RS01610 (M1F45_01605) | 359550..359759 | - | 210 | WP_000642492.1 | hypothetical protein | - |
| M1F45_RS01615 (M1F45_01610) | 359815..360060 | + | 246 | WP_001025401.1 | DUF2829 domain-containing protein | - |
| M1F45_RS01620 (M1F45_01615) | 360029..360394 | - | 366 | WP_001128433.1 | hypothetical protein | - |
| M1F45_RS01625 (M1F45_01620) | 360449..360664 | + | 216 | WP_001097552.1 | hypothetical protein | - |
| M1F45_RS01630 (M1F45_01625) | 360689..360952 | + | 264 | WP_001124160.1 | helix-turn-helix domain-containing protein | - |
| M1F45_RS01635 (M1F45_01630) | 360965..361135 | + | 171 | WP_031920869.1 | DUF1270 domain-containing protein | - |
| M1F45_RS01640 (M1F45_01635) | 361116..361454 | + | 339 | WP_224727996.1 | XRE family transcriptional regulator | - |
| M1F45_RS01645 (M1F45_01640) | 361519..361821 | + | 303 | WP_031838380.1 | DUF2482 family protein | - |
| M1F45_RS01650 (M1F45_01645) | 361826..362086 | + | 261 | WP_000291481.1 | DUF1108 family protein | - |
| M1F45_RS01655 (M1F45_01650) | 362099..362635 | + | 537 | WP_000999048.1 | host-nuclease inhibitor Gam family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 354502..401166 | 46664 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18074.46 Da Isoelectric Point: 4.6915
>T243146 WP_000525004.1 NZ_CP096540:c357883-357422 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T243146 NZ_OW970357:c4768823-4768539 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12063.56 Da Isoelectric Point: 6.4736
>AT243146 WP_000333630.1 NZ_CP096540:c358210-357896 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
Download Length: 315 bp
>AT243146 NZ_OW970357:c4769055-4768813 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2I7Y5B3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E7YIA0 |