Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1591448..1592245 Replicon chromosome
Accession NZ_CP096539
Organism Staphylococcus aureus strain RIVM_M047065

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag M1F46_RS07665 Protein ID WP_000525004.1
Coordinates 1591784..1592245 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0C2LD36
Locus tag M1F46_RS07660 Protein ID WP_001260487.1
Coordinates 1591448..1591771 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1F46_RS07585 (M1F46_07575) 1586875..1587411 - 537 WP_000999048.1 host-nuclease inhibitor Gam family protein -
M1F46_RS07590 (M1F46_07580) 1587424..1587684 - 261 WP_000291481.1 DUF1108 family protein -
M1F46_RS07595 (M1F46_07585) 1587689..1587991 - 303 WP_031838380.1 DUF2482 family protein -
M1F46_RS07600 (M1F46_07590) 1588056..1588370 - 315 WP_031838381.1 hypothetical protein -
M1F46_RS07605 (M1F46_07595) 1588375..1588545 - 171 WP_031838382.1 DUF1270 domain-containing protein -
M1F46_RS07610 (M1F46_07600) 1588558..1588821 - 264 WP_001124160.1 helix-turn-helix domain-containing protein -
M1F46_RS07615 (M1F46_07605) 1588846..1589061 - 216 WP_001097552.1 hypothetical protein -
M1F46_RS07620 (M1F46_07610) 1589116..1589481 + 366 WP_016170627.1 hypothetical protein -
M1F46_RS07625 (M1F46_07615) 1589450..1589695 - 246 WP_001025401.1 DUF2829 domain-containing protein -
M1F46_RS07630 (M1F46_07620) 1589751..1589960 + 210 WP_000642492.1 hypothetical protein -
M1F46_RS07635 (M1F46_07625) 1589950..1590093 - 144 WP_000939498.1 hypothetical protein -
M1F46_RS07640 (M1F46_07630) 1590164..1590376 + 213 WP_000362644.1 hypothetical protein -
M1F46_RS07645 (M1F46_07635) 1590417..1590566 - 150 WP_000771849.1 hypothetical protein -
M1F46_RS07650 (M1F46_07640) 1590581..1591024 - 444 WP_000435362.1 hypothetical protein -
M1F46_RS07655 (M1F46_07645) 1591006..1591284 - 279 WP_267441881.1 helix-turn-helix transcriptional regulator -
M1F46_RS07660 (M1F46_07650) 1591448..1591771 + 324 WP_001260487.1 helix-turn-helix transcriptional regulator Antitoxin
M1F46_RS07665 (M1F46_07655) 1591784..1592245 + 462 WP_000525004.1 hypothetical protein Toxin
M1F46_RS07670 (M1F46_07660) 1592263..1592847 + 585 WP_000825948.1 hypothetical protein -
M1F46_RS07675 (M1F46_07665) 1593077..1593223 + 147 WP_001795334.1 hypothetical protein -
M1F46_RS07680 (M1F46_07670) 1593220..1593834 - 615 WP_000191464.1 hypothetical protein -
M1F46_RS07685 (M1F46_07675) 1593960..1595165 + 1206 WP_031585161.1 tyrosine-type recombinase/integrase -
M1F46_RS07690 (M1F46_07680) 1595208..1597235 - 2028 WP_014532489.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - gnd 1550170..1617753 67583


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T243139 WP_000525004.1 NZ_CP096539:1591784-1592245 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T243139 NZ_OW970357:835736-836146 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12431.09 Da        Isoelectric Point: 9.3811

>AT243139 WP_001260487.1 NZ_CP096539:1591448-1591771 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT243139 NZ_OW970357:835489-835755 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0C2LD36

References