243107

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2182516..2183030 Replicon chromosome
Accession NZ_CP096530
Organism Staphylococcus aureus strain RIVM_M084526

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag M1F49_RS10875 Protein ID WP_000581792.1
Coordinates 2182516..2182725 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag M1F49_RS10880 Protein ID WP_000138932.1
Coordinates 2182737..2183030 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1F49_RS10855 (M1F49_10850) 2178027..2179382 - 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
M1F49_RS10860 (M1F49_10855) 2179397..2180467 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
M1F49_RS10865 (M1F49_10860) 2180785..2181987 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
M1F49_RS10870 (M1F49_10865) 2182251..2182388 - 138 WP_000828354.1 Lmo0850 family protein -
M1F49_RS10875 (M1F49_10870) 2182516..2182725 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
M1F49_RS10880 (M1F49_10875) 2182737..2183030 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
M1F49_RS10885 (M1F49_10880) 2183196..2184680 + 1485 WP_000571550.1 cardiolipin synthase -
M1F49_RS10890 (M1F49_10885) 2184708..2185355 + 648 WP_001187614.1 HD domain-containing protein -
M1F49_RS10895 (M1F49_10890) 2185827..2185889 + 63 Protein_2105 hypothetical protein -
M1F49_RS10900 (M1F49_10895) 2185867..2187182 - 1316 Protein_2106 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T243107 WP_000581792.1 NZ_CP096530:c2182725-2182516 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T243107 NZ_OW969904:c4417550-4417173 [Citrobacter freundii]
ATGCAAACCCAATCTATACACCCTGTACGGGCGACGGCGTCACGCCCATCTCCTGTCGATATCTGGCAAACCCTGTTGAC
GTACCTCCTGGAGCAACATTACGGGCTCACACTTAACGACACCCCGTTTGGCAACGACAGGGTGATCCAGGAGCATATTG
AGGCTGGTATCTCACTGTGCGATGGCGTCAATTTTATCGTCGAAAAGTACGAACTGGTCCGTATCGATCGTCACGGTTTC
AGCACAGAAACACAGTCACCGCTTATTGGCAGCATCGATATCCTTCGTGCACGAAAAGCGACCGGGCTGATGACCCGCAA
CGATTACAAAGTGGTCACCGACATCACCACCGGCAAATACAGCGGGGGGACACGATGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT243107 WP_000138932.1 NZ_CP096530:c2183030-2182737 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT243107 NZ_OW969904:c4417972-4417613 [Citrobacter freundii]
ATGCCAGACATCAACACCACCCAAAATGACAATATGGATGCACCGAGCTGGGGCCTGCATCGCGATATCACACCGTGTTT
TGGCGCACGACTGGTGCAGGAAGGCAACTGCCTGCATTACCTGGCTGACCGCGCCAGCATCACCGGTCAATTCAGCGAGG
CGGATTTGCGCCATCTGGATCAGGTTTTTCCGCTGATGCTCAAACAGCTTGAGTTGATGTTGGTATCCGGTGAGCTCAAC
CCACGCCACCAGCACTGCGTCACGTTGTATTACAATGGTCTCATCTGCGAAGCGGACACACTGGGCAGTTGTGGTTATAT
CTACCTCGCGATTTATCCGGGGGAACCGCCAGCAGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References