Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 904656..905132 | Replicon | chromosome |
| Accession | NZ_CP096530 | ||
| Organism | Staphylococcus aureus strain RIVM_M084526 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | T1Y7S2 |
| Locus tag | M1F49_RS04435 | Protein ID | WP_000052076.1 |
| Coordinates | 904656..904844 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | M1F49_RS04440 | Protein ID | WP_001059690.1 |
| Coordinates | 904872..905132 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M1F49_RS04405 (M1F49_04405) | 900216..901388 | - | 1173 | WP_000195429.1 | IS256-like element IS256 family transposase | - |
| M1F49_RS04410 (M1F49_04410) | 901508..902194 | + | 687 | WP_001574556.1 | thermonuclease family protein | - |
| M1F49_RS04415 (M1F49_04415) | 902551..902751 | + | 201 | WP_001059082.1 | cold-shock protein | - |
| M1F49_RS04420 (M1F49_04420) | 903248..903466 | - | 219 | WP_000005881.1 | hypothetical protein | - |
| M1F49_RS04425 (M1F49_04425) | 903527..903811 | - | 285 | WP_001004403.1 | hypothetical protein | - |
| M1F49_RS04430 (M1F49_04430) | 903899..904468 | - | 570 | WP_001106655.1 | lipoprotein N-acylation protein LnsA | - |
| M1F49_RS04435 (M1F49_04435) | 904656..904844 | - | 189 | WP_000052076.1 | hypothetical protein | Toxin |
| M1F49_RS04440 (M1F49_04440) | 904872..905132 | - | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| M1F49_RS04445 (M1F49_04445) | 905474..905677 | + | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| M1F49_RS04450 (M1F49_04450) | 905674..905910 | - | 237 | WP_000368687.1 | hypothetical protein | - |
| M1F49_RS04455 (M1F49_04455) | 906135..906716 | + | 582 | WP_001140696.1 | histidine phosphatase family protein | - |
| M1F49_RS04460 (M1F49_04460) | 906789..907406 | - | 618 | WP_000255562.1 | LysE/ArgO family amino acid transporter | - |
| M1F49_RS04465 (M1F49_04465) | 907555..908049 | - | 495 | WP_000569881.1 | GNAT family N-acetyltransferase | - |
| M1F49_RS04470 (M1F49_04470) | 908448..908870 | - | 423 | WP_000974452.1 | organic hydroperoxide resistance protein | - |
| M1F49_RS04475 (M1F49_04475) | 909018..909734 | + | 717 | WP_000150026.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 900216..901388 | 1172 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T243103 WP_000052076.1 NZ_CP096530:c904844-904656 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T243103 NZ_OW969904:892602-893009 [Citrobacter freundii]
GTGGTCCAGTGGCAATCTGATTTACGCGTATCATGGCGCGCGCAGTGGCTTTCACTGCTAATTCATGGGCTGGTCGCGGT
GTTTATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGCTGGTTTTGCTCTCTCTGGTGGTATTCGATAGCG
TTCGCAGTCAGCGTCGAATCAACGCCTGTCAGGGTGAGATTCGGCTGTTGATGGATGGTCGTCTGCGCTGGCAAGGGCAA
GAGTGGTCTATCGTTAGCGCCCCCTGGATGGTTAAAACAGGCATGATGCTGCGTTTGCGCTCTGATGCCGGAAAACGTCA
ACATTTGTGGCTGGCGGCAGACAGTATGGATGATGCAGAGTGGCGGGATTTACGGCGGTTGATGCTGCAAAAGGCGAAGC
AGAAGTAG
GTGGTCCAGTGGCAATCTGATTTACGCGTATCATGGCGCGCGCAGTGGCTTTCACTGCTAATTCATGGGCTGGTCGCGGT
GTTTATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGCTGGTTTTGCTCTCTCTGGTGGTATTCGATAGCG
TTCGCAGTCAGCGTCGAATCAACGCCTGTCAGGGTGAGATTCGGCTGTTGATGGATGGTCGTCTGCGCTGGCAAGGGCAA
GAGTGGTCTATCGTTAGCGCCCCCTGGATGGTTAAAACAGGCATGATGCTGCGTTTGCGCTCTGATGCCGGAAAACGTCA
ACATTTGTGGCTGGCGGCAGACAGTATGGATGATGCAGAGTGGCGGGATTTACGGCGGTTGATGCTGCAAAAGGCGAAGC
AGAAGTAG
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT243103 WP_001059690.1 NZ_CP096530:c905132-904872 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT243103 NZ_OW969904:892355-892621 [Citrobacter freundii]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGCCGCGGTATGCGCGAGCTGGACATCTCGATCATGCCGTT
TTTCGAACATGAATATGACAGCTTAAGTGACGAAGAAAAACGTATCTTTATCCGTCTGCTAGAATGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCATGGGAAACCAGCTGATGCTGAGCTGGAGCAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGCCGCGGTATGCGCGAGCTGGACATCTCGATCATGCCGTT
TTTCGAACATGAATATGACAGCTTAAGTGACGAAGAAAAACGTATCTTTATCCGTCTGCTAGAATGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCATGGGAAACCAGCTGATGCTGAGCTGGAGCAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VP18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |