Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 904656..905132 Replicon chromosome
Accession NZ_CP096530
Organism Staphylococcus aureus strain RIVM_M084526

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag M1F49_RS04435 Protein ID WP_000052076.1
Coordinates 904656..904844 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag M1F49_RS04440 Protein ID WP_001059690.1
Coordinates 904872..905132 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1F49_RS04405 (M1F49_04405) 900216..901388 - 1173 WP_000195429.1 IS256-like element IS256 family transposase -
M1F49_RS04410 (M1F49_04410) 901508..902194 + 687 WP_001574556.1 thermonuclease family protein -
M1F49_RS04415 (M1F49_04415) 902551..902751 + 201 WP_001059082.1 cold-shock protein -
M1F49_RS04420 (M1F49_04420) 903248..903466 - 219 WP_000005881.1 hypothetical protein -
M1F49_RS04425 (M1F49_04425) 903527..903811 - 285 WP_001004403.1 hypothetical protein -
M1F49_RS04430 (M1F49_04430) 903899..904468 - 570 WP_001106655.1 lipoprotein N-acylation protein LnsA -
M1F49_RS04435 (M1F49_04435) 904656..904844 - 189 WP_000052076.1 hypothetical protein Toxin
M1F49_RS04440 (M1F49_04440) 904872..905132 - 261 WP_001059690.1 hypothetical protein Antitoxin
M1F49_RS04445 (M1F49_04445) 905474..905677 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
M1F49_RS04450 (M1F49_04450) 905674..905910 - 237 WP_000368687.1 hypothetical protein -
M1F49_RS04455 (M1F49_04455) 906135..906716 + 582 WP_001140696.1 histidine phosphatase family protein -
M1F49_RS04460 (M1F49_04460) 906789..907406 - 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
M1F49_RS04465 (M1F49_04465) 907555..908049 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
M1F49_RS04470 (M1F49_04470) 908448..908870 - 423 WP_000974452.1 organic hydroperoxide resistance protein -
M1F49_RS04475 (M1F49_04475) 909018..909734 + 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 900216..901388 1172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T243103 WP_000052076.1 NZ_CP096530:c904844-904656 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T243103 NZ_OW969904:892602-893009 [Citrobacter freundii]
GTGGTCCAGTGGCAATCTGATTTACGCGTATCATGGCGCGCGCAGTGGCTTTCACTGCTAATTCATGGGCTGGTCGCGGT
GTTTATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGCTGGTTTTGCTCTCTCTGGTGGTATTCGATAGCG
TTCGCAGTCAGCGTCGAATCAACGCCTGTCAGGGTGAGATTCGGCTGTTGATGGATGGTCGTCTGCGCTGGCAAGGGCAA
GAGTGGTCTATCGTTAGCGCCCCCTGGATGGTTAAAACAGGCATGATGCTGCGTTTGCGCTCTGATGCCGGAAAACGTCA
ACATTTGTGGCTGGCGGCAGACAGTATGGATGATGCAGAGTGGCGGGATTTACGGCGGTTGATGCTGCAAAAGGCGAAGC
AGAAGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT243103 WP_001059690.1 NZ_CP096530:c905132-904872 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT243103 NZ_OW969904:892355-892621 [Citrobacter freundii]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGCCGCGGTATGCGCGAGCTGGACATCTCGATCATGCCGTT
TTTCGAACATGAATATGACAGCTTAAGTGACGAAGAAAAACGTATCTTTATCCGTCTGCTAGAATGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCATGGGAAACCAGCTGATGCTGAGCTGGAGCAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References