Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1384174..1384969 Replicon chromosome
Accession NC_013361
Organism Escherichia coli O26:H11 str. 11368

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag ECO26_RS07195 Protein ID WP_000854914.1
Coordinates 1384595..1384969 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7U9LM11
Locus tag ECO26_RS07190 Protein ID WP_001280953.1
Coordinates 1384174..1384548 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECO26_RS07150 1379529..1380434 + 906 WP_000203541.1 chemotaxis protein -
ECO26_RS07155 1380431..1381501 + 1071 WP_000102669.1 patatin-like phospholipase family protein -
ECO26_RS07165 1381841..1382659 + 819 WP_001234682.1 DUF945 domain-containing protein -
ECO26_RS07170 1382750..1383235 + 486 WP_000214398.1 antirestriction protein -
ECO26_RS07175 1383251..1383727 + 477 WP_001186738.1 RadC family protein -
ECO26_RS07180 1383790..1384011 + 222 WP_000692323.1 DUF987 domain-containing protein -
ECO26_RS07190 1384174..1384548 + 375 WP_001280953.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ECO26_RS07195 1384595..1384969 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
ECO26_RS07200 1384966..1385457 + 492 WP_000976857.1 hypothetical protein -
ECO26_RS07205 1385469..1385666 + 198 WP_000839282.1 DUF957 domain-containing protein -
ECO26_RS07210 1385751..1386593 + 843 WP_001280481.1 DUF4942 domain-containing protein -
ECO26_RS07220 1387064..1388002 + 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
ECO26_RS07225 1388057..1388794 + 738 WP_000283664.1 zinc-binding phosphatase -
ECO26_RS07230 1388818..1389372 + 555 WP_001001902.1 molecular chaperone YcdY -
ECO26_RS07235 1389474..1389966 + 493 Protein_1358 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 1372433..1395531 23098


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T24309 WP_000854914.1 NC_013361:1384595-1384969 [Escherichia coli O26:H11 str. 11368]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T24309 NC_013361:1384595-1384969 [Escherichia coli O26:H11 str. 11368]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCTTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13734.56 Da        Isoelectric Point: 6.6249

>AT24309 WP_001280953.1 NC_013361:1384174-1384548 [Escherichia coli O26:H11 str. 11368]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPALATTS

Download         Length: 375 bp

>AT24309 NC_013361:1384174-1384548 [Escherichia coli O26:H11 str. 11368]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACTCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LM11

References