Detailed information of TA system TA243084

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 1854654..1855130
• Replicon: chromosome
• Accession: NZ_CP096526
• Organism: Staphylococcus aureus strain RIVM_M087195

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: M1F51_RS09100
• Protein ID: WP_000052076.1
• Coordinates: 1854942..1855130 (+)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: M1F51_RS09095
• Protein ID: WP_001059690.1
• Coordinates: 1854654..1854914 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1F51_RS09060 (M1F51_09035)	1850052..1850768	-	717	WP_000150026.1	type I 3-dehydroquinate dehydratase	-
M1F51_RS09065 (M1F51_09040)	1850916..1851338	+	423	WP_000974452.1	organic hydroperoxide resistance protein	-
M1F51_RS09070 (M1F51_09045)	1851737..1852231	+	495	WP_000569881.1	GNAT family N-acetyltransferase	-
M1F51_RS09075 (M1F51_09050)	1852380..1852997	+	618	WP_000255562.1	LysE/ArgO family amino acid transporter	-
M1F51_RS09080 (M1F51_09055)	1853070..1853651	-	582	WP_001140696.1	histidine phosphatase family protein	-
M1F51_RS09085 (M1F51_09060)	1853876..1854112	+	237	WP_000368687.1	hypothetical protein	-
M1F51_RS09090 (M1F51_09065)	1854109..1854312	-	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
M1F51_RS09095 (M1F51_09070)	1854654..1854914	+	261	WP_001059690.1	hypothetical protein	Antitoxin
M1F51_RS09100 (M1F51_09075)	1854942..1855130	+	189	WP_000052076.1	hypothetical protein	Toxin
M1F51_RS09105 (M1F51_09080)	1855318..1855887	+	570	WP_001106655.1	lipoprotein N-acylation protein LnsA	-
M1F51_RS09110 (M1F51_09085)	1855975..1856259	+	285	WP_001004403.1	hypothetical protein	-
M1F51_RS09115 (M1F51_09090)	1856320..1856538	+	219	WP_000005881.1	hypothetical protein	-
M1F51_RS09120 (M1F51_09095)	1857035..1857235	-	201	WP_001059082.1	cold-shock protein	-
M1F51_RS09125 (M1F51_09100)	1857592..1858278	-	687	WP_001574556.1	thermonuclease family protein	-
M1F51_RS09130 (M1F51_09105)	1858619..1859101	-	483	WP_000824489.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-57)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-68)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T243084 WP_000052076.1 NZ_CP096526:1854942-1855130 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T243084 NZ_OW969711:2307294-2307470 [Citrobacter koseri]
GTGAAGCAGAGCGAGTTCAGACGCTGGCTTGAATCTCAGGGAGTCGATGTAACAAATGGAACGAATCATTTGAAGTTGAG
ATATCACGACAAACGAAGCGTCATGCCCAGACATCCTGGTGATGAAATTAAAGACACCCTGCGTAAAGCAATACTAAAGC
AGCTTGGTTTGAATTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT243084 WP_001059690.1 NZ_CP096526:1854654-1854914 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT243084 NZ_OW969711:2307517-2307933 [Citrobacter koseri]
ATGCGTTATCCCGTCAATCTCATTCCCGCAGAAGAAGGGGGTTATGTTGTGTCGTTCCCGGACATTCCAGAGGCGTTAAC
ACAAGGTGACACCCGCCATGAATCTCTCGAAGCCGCGCAGGGCGCATTAGTCACCGCCTTTGAATTTTATTTTGAAGATA
ACCAGCCAATTCCTTTACCTTCAATGGTTGATGAAGCTGATGATTATGTGGAGATTCCTCTTAGCATTGCGTCTAAAGTC
CTTTTGTTGAATGCGTTCCTTGAATCAAAAATCACGCAGCAGGAGCTGGCGAGGCGCATTGGCAGACCCAAGCAGGAAAT
TACCCGACTATTCGACTTGAAACACGCAACGAAAATCGATGCTGTACAGATTGCGGCCAGAGCATTGGGTAAAGAGTTAT
CGCTGACTATGCTTTAG

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56