Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 799715..800491 Replicon chromosome
Accession NZ_CP096526
Organism Staphylococcus aureus strain RIVM_M087195

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag M1F51_RS04035 Protein ID WP_000031108.1
Coordinates 800339..800491 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag M1F51_RS04030 Protein ID WP_001251224.1
Coordinates 799715..800314 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1F51_RS04010 (M1F51_03990) 795631..797088 + 1458 WP_000649908.1 ABC transporter permease subunit -
M1F51_RS04015 (M1F51_03995) 797081..797803 + 723 WP_031774878.1 amino acid ABC transporter ATP-binding protein -
M1F51_RS04020 (M1F51_04000) 797954..799081 + 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
M1F51_RS04025 (M1F51_04005) 799086..799556 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
M1F51_RS04030 (M1F51_04010) 799715..800314 + 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
M1F51_RS04035 (M1F51_04015) 800339..800491 + 153 WP_000031108.1 SAS053 family protein Toxin
M1F51_RS04040 (M1F51_04020) 801034..801429 + 396 WP_000901018.1 hypothetical protein -
M1F51_RS04045 (M1F51_04025) 801625..803010 + 1386 WP_000116238.1 class II fumarate hydratase -
M1F51_RS04050 (M1F51_04030) 803465..804286 - 822 WP_000669380.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T243083 WP_000031108.1 NZ_CP096526:800339-800491 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T243083 NZ_OW969711:1980947-1981050 [Citrobacter koseri]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT243083 WP_001251224.1 NZ_CP096526:799715-800314 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT243083 NZ_OW969711:c1981057-1980912 [Citrobacter koseri]
AACAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References