Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 345033..345821 Replicon chromosome
Accession NZ_CP096526
Organism Staphylococcus aureus strain RIVM_M087195

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag M1F51_RS01520 Protein ID WP_000525004.1
Coordinates 345033..345494 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag M1F51_RS01525 Protein ID WP_000333630.1
Coordinates 345507..345821 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1F51_RS01495 (M1F51_01485) 340085..342019 + 1935 Protein_296 YSIRK domain-containing triacylglycerol lipase Lip2/Geh -
M1F51_RS01500 (M1F51_01490) 342113..343318 - 1206 WP_031794994.1 tyrosine-type recombinase/integrase -
M1F51_RS01505 (M1F51_01495) 343444..344058 + 615 WP_000191459.1 hypothetical protein -
M1F51_RS01510 (M1F51_01500) 344055..344201 - 147 WP_078067907.1 hypothetical protein -
M1F51_RS01515 (M1F51_01505) 344431..345015 - 585 WP_000825948.1 hypothetical protein -
M1F51_RS01520 (M1F51_01510) 345033..345494 - 462 WP_000525004.1 hypothetical protein Toxin
M1F51_RS01525 (M1F51_01515) 345507..345821 - 315 WP_000333630.1 helix-turn-helix transcriptional regulator Antitoxin
M1F51_RS01530 (M1F51_01520) 345973..346209 + 237 WP_001121027.1 helix-turn-helix transcriptional regulator -
M1F51_RS01535 (M1F51_01525) 346223..346999 + 777 WP_001148544.1 Rha family transcriptional regulator -
M1F51_RS01540 (M1F51_01530) 347028..347177 + 150 WP_189683193.1 hypothetical protein -
M1F51_RS01545 (M1F51_01535) 347218..347430 - 213 WP_000362644.1 hypothetical protein -
M1F51_RS01550 (M1F51_01540) 347500..347697 + 198 WP_001148860.1 hypothetical protein -
M1F51_RS01555 (M1F51_01545) 347684..348064 - 381 WP_000773059.1 DUF2513 domain-containing protein -
M1F51_RS01560 (M1F51_01550) 348131..348274 + 144 WP_000939498.1 hypothetical protein -
M1F51_RS01565 (M1F51_01555) 348264..348473 - 210 WP_000642492.1 hypothetical protein -
M1F51_RS01570 (M1F51_01560) 348529..348744 + 216 WP_001097552.1 hypothetical protein -
M1F51_RS01575 (M1F51_01565) 348769..349032 + 264 WP_016187436.1 helix-turn-helix domain-containing protein -
M1F51_RS01580 (M1F51_01570) 349045..349206 + 162 WP_001285948.1 DUF1270 domain-containing protein -
M1F51_RS01585 (M1F51_01575) 349285..349608 + 324 WP_000174994.1 hypothetical protein -
M1F51_RS01590 (M1F51_01580) 349623..349985 + 363 WP_031794995.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 342113..388529 46416


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T243082 WP_000525004.1 NZ_CP096526:c345494-345033 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T243082 NZ_OW969711:833376-833783 [Citrobacter koseri]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCCTGGCGCGCACAATGGCTCTCTTTGCTCATTCATGGGCTTGTCGCCGC
ATTGGTTTTATTGATGCCCTGGCCATTGAGCTACACGCCGCTCTGGCTGATATTGCTTTCGCTGGTGGTGTTCGACTGTG
TGCGCAGTCAGCGGCGGATTAATACCCGGCAGGGCGAAATTAAACTGCTGATGGATGGGCGTTTACGTTGGCAAGGGCAA
GACTGGACGATTCAGGGCCCGCCCTGGATGCTTAAAACTGGCATGATGCTGCGTTTGCGCGCCGACAGCGGGAAGCGTCA
GCACTTGTGGCTGGCGGCAGACAGCATGGATGACGCCGAGTGGCGGGATTTACGGCGGTTAATGTTGCAACAGGCGACGC
AGGGGTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT243082 WP_000333630.1 NZ_CP096526:c345821-345507 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT243082 NZ_OW969711:833129-833395 [Citrobacter koseri]
ATGGATATTAATAACAAAGCACGTATTCATTGGGCATGCCGTCGCGGTATGCGTGAGCTCGACATTTCCATCATGCCGTT
TTTCGAACATGAGTACGATAACTTAAGCGATGAAGAAAAATGCATCTTTGTTCGTTTGCTGGAATGCGACGATCCTGATT
TATTTAACTGGTTGATGAACCACGGTAAACCGGGTGATGCAGAGCTGGAACAAATGGTGAAACTCATCCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References