Detailed information of TA system TA024308

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): paaR-paaA-parE/-
• Location: 1177260..1177738
• Replicon: chromosome
• Accession: NC_013361
• Organism: Escherichia coli O26:H11 str. 11368

Toxin (Protein)

• Gene name: parE_1
• Uniprot ID: A0A891SFN9
• Locus tag: ECO26_RS05825
• Protein ID: WP_001303876.1
• Coordinates: 1177260..1177547 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: Q8XD67
• Locus tag: ECO26_RS05830
• Protein ID: WP_000536233.1
• Coordinates: 1177547..1177738 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECO26_RS05800	1172483..1174933	-	2451	WP_000048583.1	exonuclease	-
ECO26_RS05805	1175027..1175218	-	192	WP_001098307.1	DUF1482 family protein	-
ECO26_RS05810	1175215..1175403	-	189	WP_000413705.1	cell division inhibition protein DicB	-
ECO26_RS05815	1175971..1176180	+	210	WP_001133037.1	hypothetical protein	-
ECO26_RS05820	1176181..1176819	-	639	WP_000394543.1	hypothetical protein	-
ECO26_RS30630	1176831..1176983	-	153	WP_000380316.1	DUF1391 family protein	-
ECO26_RS05825	1177260..1177547	-	288	WP_001303876.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ECO26_RS05830	1177547..1177738	-	192	WP_000536233.1	hypothetical protein	Antitoxin
ECO26_RS05835	1177766..1178167	-	402	WP_000986592.1	helix-turn-helix domain-containing protein	-
ECO26_RS05840	1178276..1178548	+	273	WP_000887453.1	helix-turn-helix domain-containing protein	-
ECO26_RS05845	1178532..1178957	+	426	WP_000693855.1	Rha family transcriptional regulator	-
ECO26_RS31290	1179164..1179619	-	456	WP_000273724.1	hypothetical protein	-
ECO26_RS05855	1179698..1180813	+	1116	WP_001205821.1	hypothetical protein	-
ECO26_RS05860	1180820..1181566	+	747	WP_000788742.1	ATP-binding protein	-
ECO26_RS05865	1181588..1182358	+	771	WP_000451007.1	DUF1627 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1163821..1184265	20444

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10978.84 Da
• Isoelectric Point: 10.1360

>T24308 WP_001303876.1 NC_013361:c1177547-1177260 [Escherichia coli O26:H11 str. 11368]
MLPILWLPSARDDLRQIITYIAKENPPAARRLKIRIETSVLPLSEHPYLYPPSERVSGLREIVTHPNYIILYRVAASSIE
IVSVTHSRRQFPFSI

Nucleotide

• Length: 288 bp

>T24308 NC_013361:c1177547-1177260 [Escherichia coli O26:H11 str. 11368]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7025.80 Da
• Isoelectric Point: 4.0270

>AT24308 WP_000536233.1 NC_013361:c1177738-1177547 [Escherichia coli O26:H11 str. 11368]
MGTALSPIVSEFETTEQENSYNEWLRTKVTSSLADTRPAIPHDEVMAEMENLIAQIAVTNKSE

Nucleotide

• Length: 192 bp

>AT24308 NC_013361:c1177738-1177547 [Escherichia coli O26:H11 str. 11368]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA