243078

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2131282..2131796 Replicon chromosome
Accession NZ_CP096522
Organism Staphylococcus aureus strain RIVM_M085090

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag M1F52_RS10410 Protein ID WP_000581792.1
Coordinates 2131282..2131491 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag M1F52_RS10415 Protein ID WP_000138932.1
Coordinates 2131503..2131796 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1F52_RS10390 (M1F52_10370) 2126793..2128148 - 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
M1F52_RS10395 (M1F52_10375) 2128163..2129233 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
M1F52_RS10400 (M1F52_10380) 2129551..2130753 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
M1F52_RS10405 (M1F52_10385) 2131017..2131154 - 138 WP_000828354.1 Lmo0850 family protein -
M1F52_RS10410 (M1F52_10390) 2131282..2131491 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
M1F52_RS10415 (M1F52_10395) 2131503..2131796 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
M1F52_RS10420 (M1F52_10400) 2131962..2133446 + 1485 WP_000571550.1 cardiolipin synthase -
M1F52_RS10425 (M1F52_10405) 2133474..2134121 + 648 WP_001187614.1 HD domain-containing protein -
M1F52_RS10430 (M1F52_10410) 2134678..2134740 + 63 Protein_2013 hypothetical protein -
M1F52_RS10435 (M1F52_10415) 2134718..2136033 - 1316 Protein_2014 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T243078 WP_000581792.1 NZ_CP096522:c2131491-2131282 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T243078 NZ_OW969691:c2770920-2770615 [Citrobacter koseri]
ATGCCAAAGAAACTTGTCAGTATTGAAGACTTCCGTGACCAGTGGCTGGATGATTTTTTTATGTACTCTGCACCACATAA
GAAAATTCCCCCGGATATACATTCAGCATTGGCCCGTAAGCTCGATATCATAAACGCGGCAGTGAGCTACAAGGATTTGA
AGTCACCGCCGGGTAACAGATACGAAGAACTGGAAGGTAAATTGCAGGAATATTCTTCGATAAGAGTTAACAAGCAATAT
CGTTTGATATTCAAATGGGTGAACGGCAAGGCACAAGACCTCTACCTTGATCCACATGAGTATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT243078 WP_000138932.1 NZ_CP096522:c2131796-2131503 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT243078 NZ_OW969691:c2770527-2770186 [Citrobacter koseri]
ATGAACCAGGCAACCAGAAAACCCACGACAGTTGGTGATATCCTTCTGTATGAATACCTGGAACCGCTTGATCTCAAAAT
TAATGATCTCGCGGAAATGTTGCAGGTGCATCGTAATACCGCCAGCGCATTGGTTAACAACAATCGTAAACTCACGACTG
ACATGGCTTTTCGCCTGTCTAAAGTTTTCGATACCTCTGTAGAGTTCTGGATGAACCTGCAAACTGCTGTAGATGTATGG
GAAACTGAAAACAATGCCCGCCTTCAGGTAGAGATGAGCAGGGTGATTACGGCGAGCGATTTTCTTGCGGAACGTCAGAA
ACAAGAAAAGAAAGTCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References