Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1959035..1959811 Replicon chromosome
Accession NZ_CP096522
Organism Staphylococcus aureus strain RIVM_M085090

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag M1F52_RS09450 Protein ID WP_000031108.1
Coordinates 1959035..1959187 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag M1F52_RS09455 Protein ID WP_074371037.1
Coordinates 1959212..1959811 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1F52_RS09435 (M1F52_09415) 1955240..1956061 + 822 WP_000669380.1 RluA family pseudouridine synthase -
M1F52_RS09440 (M1F52_09420) 1956516..1957901 - 1386 WP_000116238.1 class II fumarate hydratase -
M1F52_RS09445 (M1F52_09425) 1958097..1958492 - 396 WP_000901018.1 hypothetical protein -
M1F52_RS09450 (M1F52_09430) 1959035..1959187 - 153 WP_000031108.1 SAS053 family protein Toxin
M1F52_RS09455 (M1F52_09435) 1959212..1959811 - 600 WP_074371037.1 glucosamine-6-phosphate isomerase Antitoxin
M1F52_RS09460 (M1F52_09440) 1959970..1960440 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
M1F52_RS09465 (M1F52_09445) 1960445..1961572 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
M1F52_RS09470 (M1F52_09450) 1961723..1962445 - 723 WP_031774878.1 amino acid ABC transporter ATP-binding protein -
M1F52_RS09475 (M1F52_09455) 1962438..1963895 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T243076 WP_000031108.1 NZ_CP096522:c1959187-1959035 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T243076 NZ_OW969691:1967216-1967319 [Citrobacter koseri]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22355.53 Da        Isoelectric Point: 5.1445

>AT243076 WP_074371037.1 NZ_CP096522:c1959811-1959212 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLILQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT243076 NZ_OW969691:c1967326-1967181 [Citrobacter koseri]
AACAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure

References