Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Xre-MNT/HTH_26(antitoxin) |
Location | 1745900..1747008 | Replicon | chromosome |
Accession | NZ_CP096522 | ||
Organism | Staphylococcus aureus strain RIVM_M085090 |
Toxin (Protein)
Gene name | MNTss | Uniprot ID | A0A0M4MHJ8 |
Locus tag | M1F52_RS08440 | Protein ID | WP_002303392.1 |
Coordinates | 1745900..1746769 (-) | Length | 290 a.a. |
Antitoxin (Protein)
Gene name | Xress | Uniprot ID | B9DSK1 |
Locus tag | M1F52_RS08445 | Protein ID | WP_002303393.1 |
Coordinates | 1746784..1747008 (-) | Length | 75 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M1F52_RS08395 (M1F52_08375) | 1740995..1741303 | - | 309 | WP_000457386.1 | 50S ribosomal protein L21 | - |
M1F52_RS08400 (M1F52_08380) | 1741790..1742320 | - | 531 | WP_001259929.1 | rod shape-determining protein MreD | - |
M1F52_RS08405 (M1F52_08385) | 1742320..1743162 | - | 843 | WP_000911033.1 | rod shape-determining protein MreC | - |
M1F52_RS08410 (M1F52_08390) | 1743360..1743479 | - | 120 | WP_000840603.1 | hypothetical protein | - |
M1F52_RS08415 (M1F52_08395) | 1743553..1744026 | - | 474 | WP_001236734.1 | DUF4930 family protein | - |
M1F52_RS08420 (M1F52_08400) | 1744186..1744383 | + | 198 | WP_000025835.1 | hypothetical protein | - |
M1F52_RS08425 (M1F52_08405) | 1744500..1744784 | - | 285 | WP_000171859.1 | hypothetical protein | - |
M1F52_RS08430 (M1F52_08410) | 1744852..1744998 | - | 147 | Protein_1656 | JAB domain-containing protein | - |
M1F52_RS08435 (M1F52_08415) | 1745233..1745919 | - | 687 | WP_224103254.1 | class I SAM-dependent methyltransferase | - |
M1F52_RS08440 (M1F52_08420) | 1745900..1746769 | - | 870 | WP_002303392.1 | nucleotidyltransferase domain-containing protein | Toxin |
M1F52_RS08445 (M1F52_08425) | 1746784..1747008 | - | 225 | WP_002303393.1 | helix-turn-helix transcriptional regulator | Antitoxin |
M1F52_RS08450 (M1F52_08430) | 1747151..1747972 | - | 822 | Protein_1660 | recombinase zinc beta ribbon domain-containing protein | - |
M1F52_RS08455 (M1F52_08435) | 1748660..1749463 | - | 804 | WP_002294514.1 | lincosamide nucleotidyltransferase Lnu(B) | - |
M1F52_RS08460 (M1F52_08440) | 1749517..1751001 | - | 1485 | WP_074371031.1 | ABC-F type ribosomal protection protein Lsa(E) | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | lnu(B) / lsa(E) | - | 1744500..1752889 | 8389 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 290 a.a. Molecular weight: 32807.38 Da Isoelectric Point: 4.7269
>T243075 WP_002303392.1 NZ_CP096522:c1746769-1745900 [Staphylococcus aureus]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARSTHTENSDIDIGIYYNSDSFDLTAINQIATELDDENRNNLVVPPGAWGDW
VNGGGWLVINGCHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGAEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARSTHTENSDIDIGIYYNSDSFDLTAINQIATELDDENRNNLVVPPGAWGDW
VNGGGWLVINGCHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGAEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI
Download Length: 870 bp
>T243075 NZ_OW969691:839547-839954 [Citrobacter koseri]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCCTGGCGCGCACAATGGCTCTCTTTGCTCATTCATGGGCTTGTCGCCGC
ATTGGTTTTATTGATGCCCTGGCCATTGAGCTACACGCCGCTCTGGCTGATATTGCTTTCGCTGGTGGTGTTCGACTGTG
TGCGCAGTCAGCGGCGGATTAATACCCGGCAGGGCGAAATTAAACTGCTGATGGATGGGCGTTTACGTTGGCAAGGGCAA
GACTGGACGATTCAGGGGCCGCCTTGGATGCTTAAAACCGGCATGATGCTGCGTTTGCGCGCCGACAGCGGGAAGCGTCA
GCATTTGTGGCTGGCGGCAGACAGCATGGATGACGCCGAGTGGCGGGATTTACGGCGGTTAATGTTGCAACAGGCGACGC
AGGGGTAA
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCCTGGCGCGCACAATGGCTCTCTTTGCTCATTCATGGGCTTGTCGCCGC
ATTGGTTTTATTGATGCCCTGGCCATTGAGCTACACGCCGCTCTGGCTGATATTGCTTTCGCTGGTGGTGTTCGACTGTG
TGCGCAGTCAGCGGCGGATTAATACCCGGCAGGGCGAAATTAAACTGCTGATGGATGGGCGTTTACGTTGGCAAGGGCAA
GACTGGACGATTCAGGGGCCGCCTTGGATGCTTAAAACCGGCATGATGCTGCGTTTGCGCGCCGACAGCGGGAAGCGTCA
GCATTTGTGGCTGGCGGCAGACAGCATGGATGACGCCGAGTGGCGGGATTTACGGCGGTTAATGTTGCAACAGGCGACGC
AGGGGTAA
Antitoxin
Download Length: 75 a.a. Molecular weight: 8351.65 Da Isoelectric Point: 4.5357
>AT243075 WP_002303393.1 NZ_CP096522:c1747008-1746784 [Staphylococcus aureus]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGDEIKISNE
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGDEIKISNE
Download Length: 225 bp
>AT243075 NZ_OW969691:839300-839566 [Citrobacter koseri]
ATGGATATTAATAACAAAGCACGTATTCATTGGGCATGCCGTCGCGGTATGCGTGAGCTCGACATTTCTATCATGCCGTT
TTTCGAACATGAGTACGATAACTTAAGCGATGAAGAAAAATGCATCTTTGTTCGTTTGCTGGAATGCGACGATCCTGATT
TATTTAACTGGTTGATGAACCACGGTAAACCGGGGGATGCAGAACTGGAACAAATGGTGAAACTCATCCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGATATTAATAACAAAGCACGTATTCATTGGGCATGCCGTCGCGGTATGCGTGAGCTCGACATTTCTATCATGCCGTT
TTTCGAACATGAGTACGATAACTTAAGCGATGAAGAAAAATGCATCTTTGTTCGTTTGCTGGAATGCGACGATCCTGATT
TATTTAACTGGTTGATGAACCACGGTAAACCGGGGGATGCAGAACTGGAACAAATGGTGAAACTCATCCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0M4MHJ8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1M5SHM7 |