243074

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 906079..906555 Replicon chromosome
Accession NZ_CP096522
Organism Staphylococcus aureus strain RIVM_M085090

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag M1F52_RS04395 Protein ID WP_000052076.1
Coordinates 906079..906267 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag M1F52_RS04400 Protein ID WP_001059690.1
Coordinates 906295..906555 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1F52_RS04365 (M1F52_04350) 902108..902590 + 483 WP_000824489.1 hypothetical protein -
M1F52_RS04370 (M1F52_04355) 902931..903617 + 687 WP_001574556.1 thermonuclease family protein -
M1F52_RS04375 (M1F52_04360) 903974..904174 + 201 WP_001059082.1 cold-shock protein -
M1F52_RS04380 (M1F52_04365) 904671..904889 - 219 WP_000005881.1 hypothetical protein -
M1F52_RS04385 (M1F52_04370) 904950..905234 - 285 WP_001004403.1 hypothetical protein -
M1F52_RS04390 (M1F52_04375) 905322..905891 - 570 WP_001106655.1 lipoprotein N-acylation protein LnsA -
M1F52_RS04395 (M1F52_04380) 906079..906267 - 189 WP_000052076.1 hypothetical protein Toxin
M1F52_RS04400 (M1F52_04385) 906295..906555 - 261 WP_001059690.1 hypothetical protein Antitoxin
M1F52_RS04405 (M1F52_04390) 906897..907100 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
M1F52_RS04410 (M1F52_04395) 907097..907333 - 237 WP_000368687.1 hypothetical protein -
M1F52_RS04415 (M1F52_04400) 907558..908139 + 582 WP_001140696.1 histidine phosphatase family protein -
M1F52_RS04420 (M1F52_04405) 908212..908829 - 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
M1F52_RS04425 (M1F52_04410) 908978..909472 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
M1F52_RS04430 (M1F52_04415) 909871..910293 - 423 WP_074371006.1 organic hydroperoxide resistance protein -
M1F52_RS04435 (M1F52_04420) 910441..911157 + 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T243074 WP_000052076.1 NZ_CP096522:c906267-906079 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T243074 NZ_OW969691:101080-101526 [Citrobacter koseri]
ATGGAGAATATAGTCATGATATTGCGTCAGATAAAGCAGGATGTATATAAAAGGCTTTGTGATAATCGACCTCAAGTCTT
AGAAAAGAATAGAGGGTATGGTGTTATATCTATTAGCCTTAACGGTCTAACTTTTGCTGTGCCATTGCGAAGTAATTTAA
ACCATCCTAATGGTTTCAAAACTATTTTTTTGAAAGATAAAAAAATTTGGAGTGGTTTAGATTATTCAAAAGCCTTGATT
GTTAAACCTGAGGATTTGGAGCCAGAAGCTTTTAAATTAAAAATAGAAAAAGAGTATGAGAAATTAAAAGCAAATAAGTC
CAAGATCGAGAAAGAGTTTGAGGCTTATGTTCAAGGGTATATTCTATTTGTAAAGTCTGGTTGTGGTGAAGAAAAAGCTT
ATAAATTTACCACGTTACAGTATTTTCATGATTTTTTAGGGTTGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT243074 WP_001059690.1 NZ_CP096522:c906555-906295 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT243074 NZ_OW969691:100937-100983 [Citrobacter koseri]
GATTATGTGGCGGTAGAGGCATCCCCACGTTAAATAGAACAACCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References