Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 5238847..5239481 Replicon chromosome
Accession NZ_CP096276
Organism Pimelobacter simplex strain N40

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag M0M48_RS25720 Protein ID WP_257753291.1
Coordinates 5239071..5239481 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag M0M48_RS25715 Protein ID WP_215813961.1
Coordinates 5238847..5239074 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0M48_RS25695 (M0M48_25655) 5234462..5234995 + 534 WP_215813965.1 DNA starvation/stationary phase protection protein -
M0M48_RS25700 (M0M48_25660) 5235039..5236247 + 1209 WP_257753288.1 cytochrome P450 -
M0M48_RS25705 (M0M48_25665) 5236249..5236779 + 531 WP_257753289.1 TetR family transcriptional regulator -
M0M48_RS25710 (M0M48_25670) 5236843..5238810 + 1968 WP_257753290.1 AarF/UbiB family protein -
M0M48_RS25715 (M0M48_25675) 5238847..5239074 + 228 WP_215813961.1 ribbon-helix-helix protein, CopG family Antitoxin
M0M48_RS25720 (M0M48_25680) 5239071..5239481 + 411 WP_257753291.1 PIN domain nuclease Toxin
M0M48_RS25725 (M0M48_25685) 5239471..5241822 - 2352 WP_257753292.1 arylsulfatase -
M0M48_RS25730 (M0M48_25690) 5241834..5242793 - 960 WP_257753293.1 formylglycine-generating enzyme family protein -
M0M48_RS25735 (M0M48_25695) 5242790..5244460 - 1671 WP_257753294.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-122)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-42)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15060.29 Da        Isoelectric Point: 5.6749

>T243066 WP_257753291.1 NZ_CP096276:5239071-5239481 [Pimelobacter simplex]
MTDWLIDKSALVRLAHAAERDEWRERCRRGLVRITSPTLLEAGFSARSADDWQALVAGPPVSWFPVEYLTPAIERRALDV
QRILAARGQHRAPSVPDLLIAATAELAGLVVLHLDKDFELIADVTGQQVERLGLTA

Download         Length: 411 bp

>T243066 NZ_OW969659:658618-658992 [Klebsiella oxytoca]
ATGAAATGGGTGAGCGCAAGCGAAGTCATTGCCTTTCATGATCGCATTTTACAACATCTCCCCGGCGTTAAAGGTATGTC
CGATCCTGGTCGGGCGGAAGCCATAATTTATCGTGTACAGAACCGCTTTCACTGTGAAGGGGTGAACGACATTTTTGAAC
TGGCTGCAACCTATTGGGTCGCTATCGCGCGTGGGCACATTTTTAATGATGGTAATAAGAGGACTGCTTTTTTTATCACC
ATGACGTTCCTGGCCCGCAATGGGTATCTTATCGCTGATGAAGATACCCGGTTGGAAGAACTCACTGTGCTGGCTGCGAC
AGGCGAAGCTACGGTAGTAGTTCTTGCTGATGCGTTACGGCAATTGGCGCTCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8594.56 Da        Isoelectric Point: 4.2561

>AT243066 WP_215813961.1 NZ_CP096276:5238847-5239074 [Pimelobacter simplex]
MTDLLIRNVPDEDLRRIDDKARRLGLSRADYFRRLILQEAARGVDDAEPGTDVFARFADLAQDLGDDDVMRDAWS

Download         Length: 228 bp

>AT243066 NZ_OW969659:658400-658621 [Klebsiella oxytoca]
ATGCGCTCTTATAGTACATCTGAAGCCAGACAGAATATTGCGGCCGTCATGGACGCCGCTGCCAGCGGAGAACCGATTGA
AATTACGCGGCGTGATGGAACGTCTAATGTTTTGATCAGTAAGGCTGAATATGAAACGTTTATGAATGCCAAACTTGATG
CGGAGTTTGATTTTATTATGCAGCGACACGGCCGCACAGTTAAGGCGTTGACCGATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References