Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2713356..2713870 Replicon chromosome
Accession NZ_CP096274
Organism Staphylococcus aureus strain FJ0322

Toxin (Protein)


Gene name TsdT Uniprot ID A0A641A3V2
Locus tag M1E50_RS13420 Protein ID WP_000581793.1
Coordinates 2713661..2713870 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag M1E50_RS13415 Protein ID WP_000138932.1
Coordinates 2713356..2713649 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1E50_RS13395 (2708720) 2708720..2709361 + 642 WP_000483164.1 thiamine phosphate synthase -
M1E50_RS13400 (2709447) 2709447..2710319 + 873 WP_000725802.1 membrane protein insertase YidC -
M1E50_RS13405 (2711031) 2711031..2711678 - 648 WP_001187627.1 HD domain-containing protein -
M1E50_RS13410 (2711706) 2711706..2713190 - 1485 WP_000571552.1 cardiolipin synthase -
M1E50_RS13415 (2713356) 2713356..2713649 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
M1E50_RS13420 (2713661) 2713661..2713870 + 210 WP_000581793.1 heavy metal-associated domain-containing protein Toxin
M1E50_RS13425 (2713998) 2713998..2714135 + 138 WP_000828354.1 Lmo0850 family protein -
M1E50_RS13430 (2714398) 2714398..2715600 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
M1E50_RS13435 (2715918) 2715918..2716988 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
M1E50_RS13440 (2717003) 2717003..2718361 + 1359 WP_000611466.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7809.75 Da        Isoelectric Point: 4.1008

>T243064 WP_000581793.1 NZ_CP096274:2713661-2713870 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVI

Download         Length: 210 bp

>T243064 NZ_OW969633:2537122-2537607 [Klebsiella aerogenes]
ATGGGAAAAATAAGCGCGCCTGCACCGCTATCTTCACACCATCAGATCGCGGAATTTTGTTGTGGAGAAACGGTTCTCGA
TCAATGGCTGAAACAGCGAGGATTGAAAAACCAGGCTCAGGGCGCCGCGAGAACCTTTGTGGTCTGCAAGGAAGAGAGCC
ATCAGGTGGTGGGGTTTTATTCGTTAGCAACCGGCAGCGTTAATCACACGGAAGCCACTGGCGGCCTGCGGCGCAATATG
CCCGATCCTATCCCGGTCATCATTCTCGCCCGCCTGGCGATCGACTGCGCGTATCACGGACAGGGGCTGGGAGCTGATTT
ACTCCATGATGCGCTCTTACGCAGTTATCGCGTTGCCGAAAATGTTGGCGTTCGTGCCCTGATGGTCCATGCCCTGACCG
ATAGCGCGAAACGATTCTATTTACACCACGGATTCAAAGCCTCCACCACCCAGGAACGCACACTTTTCCTCGCGTTGCCT
AAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT243064 WP_000138932.1 NZ_CP096274:2713356-2713649 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT243064 NZ_OW969633:2536868-2537134 [Klebsiella aerogenes]
ATGAAATCAGATATCCAACTCAACATCCGGGCGAAGGAGTCCCAGCGGGCGCTGATTGATGCGGCTGCCGAAATTCTGCA
CAAATCACGGACCGACTTTATTCTTGAGATGGCCTGCCAGGCGGCAGAAAACGTCATTCTCGACCGCCGGGTGTTTAACT
TAAGCGATGAGCAATACGCCGAATTTATCGACATGCTGGATGCGCCGGTTGAAGCTAACCCCGCTCTCGACAAATTGCTG
GCGAGAAAACCACAATGGGAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641A3V2

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References