Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1211986..1212463 Replicon chromosome
Accession NZ_CP096274
Organism Staphylococcus aureus strain FJ0322

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag M1E50_RS06130 Protein ID WP_000052076.1
Coordinates 1212275..1212463 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag M1E50_RS06125 Protein ID WP_001059690.1
Coordinates 1211986..1212246 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1E50_RS06090 (1207381) 1207381..1208097 - 717 WP_000150021.1 type I 3-dehydroquinate dehydratase -
M1E50_RS06095 (1208245) 1208245..1208667 + 423 WP_000974447.1 organic hydroperoxide resistance protein -
M1E50_RS06100 (1209066) 1209066..1209560 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
M1E50_RS06105 (1209714) 1209714..1210331 + 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
M1E50_RS06110 (1210404) 1210404..1210985 - 582 WP_001140690.1 histidine phosphatase family protein -
M1E50_RS06115 (1211210) 1211210..1211446 + 237 WP_000368687.1 hypothetical protein -
M1E50_RS06120 (1211443) 1211443..1211646 - 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
M1E50_RS06125 (1211986) 1211986..1212246 + 261 WP_001059690.1 hypothetical protein Antitoxin
M1E50_RS06130 (1212275) 1212275..1212463 + 189 WP_000052076.1 hypothetical protein Toxin
M1E50_RS06135 (1212651) 1212651..1213220 + 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
M1E50_RS06140 (1213308) 1213308..1213592 + 285 WP_001004395.1 hypothetical protein -
M1E50_RS06145 (1213654) 1213654..1213872 + 219 WP_000005889.1 hypothetical protein -
M1E50_RS06150 (1214367) 1214367..1214567 - 201 WP_001059082.1 cold-shock protein -
M1E50_RS06155 (1214924) 1214924..1215610 - 687 WP_001641381.1 thermonuclease family protein -
M1E50_RS06160 (1215951) 1215951..1216460 - 510 WP_000824480.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T243055 WP_000052076.1 NZ_CP096274:1212275-1212463 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T243055 NZ_OW968431:1833380-1833482 [Klebsiella quasipneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT243055 WP_001059690.1 NZ_CP096274:1211986-1212246 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT243055 NZ_OW968431:c1833486-1833339 [Klebsiella quasipneumoniae]
AGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTG
GCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGTCTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References