Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) TsaAT/-
Location 1211986..1212463 Replicon chromosome
Accession NZ_CP096272
Organism Staphylococcus aureus strain FJ0318

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag M1E49_RS06130 Protein ID WP_000052076.1
Coordinates 1212275..1212463 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag M1E49_RS06125 Protein ID WP_001059690.1
Coordinates 1211986..1212246 (+) Length 87 a.a.

Genomic Context


M1E49_RS06095M1E49_RS06100M1E49_RS06105M1E49_RS06115M1E49_RS06125M1E49_RS06130M1E49_RS06135M1E49_RS06140M1E49_RS06145M1E49_RS06090M1E49_RS06110M1E49_RS06120M1E49_RS06150M1E49_RS06155M1E49_RS06160
Location: 1208245..1208667 (423 bp)
Type: Others
Protein ID: WP_000974447.1
Location: 1209066..1209560 (495 bp)
Type: Others
Protein ID: WP_000569884.1
Location: 1209714..1210331 (618 bp)
Type: Others
Protein ID: WP_000255561.1
Location: 1211210..1211446 (237 bp)
Type: Others
Protein ID: WP_000368687.1
Location: 1211986..1212246 (261 bp)
Type: Antitoxin
Protein ID: WP_001059690.1
Location: 1212275..1212463 (189 bp)
Type: Toxin
Protein ID: WP_000052076.1
Location: 1212651..1213220 (570 bp)
Type: Others
Protein ID: WP_001106654.1
Location: 1213308..1213592 (285 bp)
Type: Others
Protein ID: WP_001004395.1
Location: 1213654..1213872 (219 bp)
Type: Others
Protein ID: WP_000005889.1
Location: 1207381..1208097 (717 bp)
Type: Others
Protein ID: WP_000150021.1
Location: 1210404..1210985 (582 bp)
Type: Others
Protein ID: WP_001140690.1
Location: 1211443..1211646 (204 bp)
Type: Others
Protein ID: WP_000145163.1
Location: 1214367..1214567 (201 bp)
Type: Others
Protein ID: WP_001059082.1
Location: 1214924..1215610 (687 bp)
Type: Others
Protein ID: WP_001641381.1
Location: 1215951..1216460 (510 bp)
Type: Others
Protein ID: WP_000824480.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
M1E49_RS06090 (1207381)1207381..1208097-717WP_000150021.1type I 3-dehydroquinate dehydratase-
M1E49_RS06095 (1208245)1208245..1208667+423WP_000974447.1organic hydroperoxide resistance protein-
M1E49_RS06100 (1209066)1209066..1209560+495WP_000569884.1GNAT family N-acetyltransferase-
M1E49_RS06105 (1209714)1209714..1210331+618WP_000255561.1LysE/ArgO family amino acid transporter-
M1E49_RS06110 (1210404)1210404..1210985-582WP_001140690.1histidine phosphatase family protein-
M1E49_RS06115 (1211210)1211210..1211446+237WP_000368687.1hypothetical protein-
M1E49_RS06120 (1211443)1211443..1211646-204WP_000145163.1sterile alpha motif-like domain-containing protein-
M1E49_RS06125 (1211986)1211986..1212246+261WP_001059690.1hypothetical proteinAntitoxin
M1E49_RS06130 (1212275)1212275..1212463+189WP_000052076.1hypothetical proteinToxin
M1E49_RS06135 (1212651)1212651..1213220+570WP_001106654.1lipoprotein N-acylation protein LnsA-
M1E49_RS06140 (1213308)1213308..1213592+285WP_001004395.1hypothetical protein-
M1E49_RS06145 (1213654)1213654..1213872+219WP_000005889.1hypothetical protein-
M1E49_RS06150 (1214367)1214367..1214567-201WP_001059082.1cold-shock protein-
M1E49_RS06155 (1214924)1214924..1215610-687WP_001641381.1thermonuclease family protein-
M1E49_RS06160 (1215951)1215951..1216460-510WP_000824480.1hypothetical protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-129)

Antitoxin

(7-47)


Sequences


Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T243039 WP_000052076.1 NZ_CP096272:1212275-1212463 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T243039 NZ_OW968348:59824-60240 [Klebsiella oxytoca]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT243039 WP_001059690.1 NZ_CP096272:1211986-1212246 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT243039 NZ_OW968348:59597-59827 [Klebsiella oxytoca]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A0E0VP18


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0E0VN56

References