Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vagCD/VapC-VagC |
Location | 17825..18468 | Replicon | plasmid pKP20-558-4 |
Accession | NZ_CP096267 | ||
Organism | Klebsiella quasipneumoniae strain KP20-558 |
Toxin (Protein)
Gene name | vagD | Uniprot ID | D8L2J9 |
Locus tag | M0M92_RS29590 | Protein ID | WP_001044770.1 |
Coordinates | 18052..18468 (+) | Length | 139 a.a. |
Antitoxin (Protein)
Gene name | vagC | Uniprot ID | D5KTK7 |
Locus tag | M0M92_RS29585 | Protein ID | WP_001261282.1 |
Coordinates | 17825..18055 (+) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M0M92_RS29550 (M0M92_29560) | 13397..14263 | - | 867 | WP_023302476.1 | replication initiation protein | - |
M0M92_RS29555 (M0M92_29565) | 14798..14902 | + | 105 | WP_032410267.1 | hypothetical protein | - |
M0M92_RS29560 (M0M92_29570) | 15031..15288 | + | 258 | WP_000764642.1 | hypothetical protein | - |
M0M92_RS29565 (M0M92_29575) | 15346..16122 | - | 777 | WP_023302478.1 | site-specific integrase | - |
M0M92_RS29570 (M0M92_29580) | 16119..16862 | - | 744 | WP_004098973.1 | hypothetical protein | - |
M0M92_RS29575 (M0M92_29585) | 16913..17263 | - | 351 | WP_000493378.1 | hypothetical protein | - |
M0M92_RS29580 (M0M92_29590) | 17407..17868 | - | 462 | WP_179135310.1 | hypothetical protein | - |
M0M92_RS29585 (M0M92_29595) | 17825..18055 | + | 231 | WP_001261282.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
M0M92_RS29590 (M0M92_29600) | 18052..18468 | + | 417 | WP_001044770.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
M0M92_RS29595 (M0M92_29605) | 18542..20104 | + | 1563 | WP_004206609.1 | AAA family ATPase | - |
M0M92_RS29600 (M0M92_29610) | 20089..21111 | + | 1023 | WP_000361404.1 | helicase UvrD | - |
M0M92_RS29605 (M0M92_29615) | 21655..22563 | + | 909 | WP_080933653.1 | HNH endonuclease | - |
M0M92_RS29610 (M0M92_29620) | 22749..23099 | - | 351 | WP_004187110.1 | DUF305 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | sul1 / qacE / ere(A) / dfrA5 | - | 1..52802 | 52802 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15106.52 Da Isoelectric Point: 7.1084
>T243032 WP_001044770.1 NZ_CP096267:18052-18468 [Klebsiella quasipneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR
Download Length: 417 bp
>T243032 NZ_OW968329:4188-4475 [Enterobacter cloacae]
ATGGAACTGAAGTGGACCAGTAAGGCACTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTACTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGTGCCGATCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTATGAACTTACTGGCCAGACTATTTGG
GGGCCGCATGGAATTCGGAAAATAAACCACGTTAAGACTATTTTTTAG
ATGGAACTGAAGTGGACCAGTAAGGCACTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTACTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTGCAGTCCCTGACACAGGTGCCGATCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTATGAACTTACTGGCCAGACTATTTGG
GGGCCGCATGGAATTCGGAAAATAAACCACGTTAAGACTATTTTTTAG
Antitoxin
Download Length: 77 a.a. Molecular weight: 8756.83 Da Isoelectric Point: 4.4692
>AT243032 WP_001261282.1 NZ_CP096267:17825-18055 [Klebsiella quasipneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL
Download Length: 231 bp
>AT243032 NZ_OW968329:3904-4188 [Enterobacter cloacae]
ATGCAAATGAAAAACAATACCGCACAAACAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGATTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCAGACAGCCTCAATACTGACAATCCGTTACCGGTGCCTCGCTGA
ATGCAAATGAAAAACAATACCGCACAAACAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGATTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCAGACAGCCTCAATACTGACAATCCGTTACCGGTGCCTCGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GYM2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GZG3 |