Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4456128..4456785 Replicon chromosome
Accession NZ_CP096263
Organism Klebsiella quasipneumoniae strain KP20-558

Toxin (Protein)


Gene name cptA Uniprot ID A0A2N4VX63
Locus tag M0M92_RS21585 Protein ID WP_023290968.1
Coordinates 4456128..4456538 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag M0M92_RS21590 Protein ID WP_002916312.1
Coordinates 4456519..4456785 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0M92_RS21565 (4452128) 4452128..4453861 - 1734 WP_044524681.1 single-stranded-DNA-specific exonuclease RecJ -
M0M92_RS21570 (4453867) 4453867..4454580 - 714 WP_248569162.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M0M92_RS21575 (4454603) 4454603..4455499 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
M0M92_RS21580 (4455600) 4455600..4456121 + 522 WP_004205324.1 flavodoxin FldB -
M0M92_RS21585 (4456128) 4456128..4456538 - 411 WP_023290968.1 protein YgfX Toxin
M0M92_RS21590 (4456519) 4456519..4456785 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
M0M92_RS21595 (4457031) 4457031..4458014 + 984 WP_023290969.1 tRNA-modifying protein YgfZ -
M0M92_RS21600 (4458171) 4458171..4458830 - 660 WP_008806429.1 hemolysin III family protein -
M0M92_RS21605 (4458994) 4458994..4459305 - 312 WP_023290970.1 N(4)-acetylcytidine aminohydrolase -
M0M92_RS21610 (4459356) 4459356..4460084 + 729 WP_032454033.1 MurR/RpiR family transcriptional regulator -
M0M92_RS21615 (4460203) 4460203..4461636 + 1434 WP_023290972.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16075.89 Da        Isoelectric Point: 11.4778

>T243028 WP_023290968.1 NZ_CP096263:c4456538-4456128 [Klebsiella quasipneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDPGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T243028 NZ_OW968328:c2915482-2915379 [Enterobacter cloacae]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT243028 WP_002916312.1 NZ_CP096263:c4456785-4456519 [Klebsiella quasipneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT243028 NZ_OW968328:2915366-2915517 [Enterobacter cloacae]
CTTTCAATCAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGC
TAAAAGTTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N4VX63

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References