Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Hha-TomB/- |
Location | 1140903..1141522 | Replicon | chromosome |
Accession | NZ_CP096263 | ||
Organism | Klebsiella quasipneumoniae strain KP20-558 |
Toxin (Protein)
Gene name | Hha | Uniprot ID | R8WYV2 |
Locus tag | M0M92_RS05380 | Protein ID | WP_002892050.1 |
Coordinates | 1140903..1141121 (-) | Length | 73 a.a. |
Antitoxin (Protein)
Gene name | TomB | Uniprot ID | J2DPF6 |
Locus tag | M0M92_RS05385 | Protein ID | WP_002892066.1 |
Coordinates | 1141148..1141522 (-) | Length | 125 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M0M92_RS05345 (1136946) | 1136946..1137209 | + | 264 | WP_004204754.1 | type B 50S ribosomal protein L31 | - |
M0M92_RS05350 (1137209) | 1137209..1137349 | + | 141 | WP_002892018.1 | type B 50S ribosomal protein L36 | - |
M0M92_RS05355 (1137346) | 1137346..1138044 | - | 699 | WP_117128677.1 | GNAT family protein | - |
M0M92_RS05360 (1138145) | 1138145..1139602 | + | 1458 | Protein_1026 | PLP-dependent aminotransferase family protein | - |
M0M92_RS05365 (1139571) | 1139571..1140041 | - | 471 | WP_064155186.1 | YlaC family protein | - |
M0M92_RS05370 (1140075) | 1140075..1140206 | + | 132 | WP_162543094.1 | hypothetical protein | - |
M0M92_RS05375 (1140178) | 1140178..1140744 | - | 567 | WP_023288643.1 | maltose O-acetyltransferase | - |
M0M92_RS05380 (1140903) | 1140903..1141121 | - | 219 | WP_002892050.1 | HHA domain-containing protein | Toxin |
M0M92_RS05385 (1141148) | 1141148..1141522 | - | 375 | WP_002892066.1 | Hha toxicity modulator TomB | Antitoxin |
M0M92_RS05390 (1142007) | 1142007..1145153 | - | 3147 | WP_023288644.1 | multidrug efflux RND transporter permease subunit AcrB | - |
M0M92_RS05395 (1145176) | 1145176..1146369 | - | 1194 | WP_023288645.1 | multidrug efflux RND transporter periplasmic adaptor subunit AcrA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 73 a.a. Molecular weight: 8628.00 Da Isoelectric Point: 8.9008
>T243018 WP_002892050.1 NZ_CP096263:c1141121-1140903 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR
Download Length: 219 bp
>T243018 NZ_OW968288:c4390439-4390266 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG
Antitoxin
Download Length: 125 a.a. Molecular weight: 14368.06 Da Isoelectric Point: 4.8989
>AT243018 WP_002892066.1 NZ_CP096263:c1141522-1141148 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC
Download Length: 375 bp
>AT243018 NZ_OW968288:c4390763-4390467 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2P8K6F2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GJ93 |