Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 475366..476154 Replicon chromosome
Accession NZ_CP096263
Organism Klebsiella quasipneumoniae strain KP20-558

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag M0M92_RS02205 Protein ID WP_119676835.1
Coordinates 475777..476154 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag M0M92_RS02200 Protein ID WP_040246534.1
Coordinates 475366..475725 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0M92_RS02165 (470734) 470734..470841 + 108 Protein_403 IS66 family insertion sequence element accessory protein TnpB -
M0M92_RS02170 (470838) 470838..471188 + 351 WP_009309933.1 IS66 family insertion sequence element accessory protein TnpB -
M0M92_RS02175 (471219) 471219..472811 + 1593 Protein_405 IS66 family transposase -
M0M92_RS02180 (472973) 472973..473791 + 819 WP_058836884.1 DUF932 domain-containing protein -
M0M92_RS02185 (474146) 474146..474610 + 465 WP_058836883.1 antirestriction protein -
M0M92_RS02190 (474622) 474622..475101 + 480 WP_058836882.1 DNA repair protein RadC -
M0M92_RS02195 (475122) 475122..475343 + 222 WP_058836881.1 DUF987 family protein -
M0M92_RS02200 (475366) 475366..475725 + 360 WP_040246534.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
M0M92_RS02205 (475777) 475777..476154 + 378 WP_119676835.1 TA system toxin CbtA family protein Toxin
M0M92_RS02210 (476151) 476151..476609 + 459 WP_058836879.1 DUF5983 family protein -
M0M92_RS02215 (476672) 476672..476875 + 204 WP_058836878.1 DUF957 domain-containing protein -
M0M92_RS02220 (476957) 476957..477802 + 846 WP_058836877.1 DUF4942 domain-containing protein -
M0M92_RS02225 (477946) 477946..478743 + 798 WP_058836876.1 helix-turn-helix transcriptional regulator -
M0M92_RS02230 (479081) 479081..480312 + 1232 Protein_416 integrase arm-type DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 465387..484064 18677


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14091.88 Da        Isoelectric Point: 6.0713

>T243017 WP_119676835.1 NZ_CP096263:475777-476154 [Klebsiella quasipneumoniae]
MQTQPLSSRQEASPRPSPVDIWQQLLSHLLDRHYGLTLNDTPFGHDCVIQEHIDAGISLCDAVNVIVEKYDLVRTDRPGF
SAETQSPLISSIDILRARKATGLMTRNDYRTVTDITTGKYREVQP

Download         Length: 378 bp

>T243017 NZ_OW968288:c4192385-4192008 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13035.78 Da        Isoelectric Point: 5.8062

>AT243017 WP_040246534.1 NZ_CP096263:475366-475725 [Klebsiella quasipneumoniae]
MSNEIPAVNHDIAEPWWGLKPTVTPCFGARLVQEGNQVHYLADRASITGQFSEADLRHLDQAFPVLLKQLELMLVSGELN
PHHQHGVTLYAKGLTCEADSLGSHGYIYIAIYPTPAATA

Download         Length: 360 bp

>AT243017 NZ_OW968288:c4192843-4192475 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References