Detailed information of TA system TA243016

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 394883..395399
• Replicon: chromosome
• Accession: NZ_CP096263
• Organism: Klebsiella quasipneumoniae strain KP20-558

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: M0M92_RS01870
• Protein ID: WP_044525202.1
• Coordinates: 395115..395399 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1C1EW86
• Locus tag: M0M92_RS01865
• Protein ID: WP_023291757.1
• Coordinates: 394883..395125 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M0M92_RS01850 (390911)	390911..391651	+	741	WP_180402639.1	KDGP aldolase family protein	-
M0M92_RS01855 (391718)	391718..392872	+	1155	WP_248569219.1	lactonase family protein	-
M0M92_RS01860 (392895)	392895..394805	+	1911	WP_248569220.1	PRD domain-containing protein	-
M0M92_RS01865 (394883)	394883..395125	+	243	WP_023291757.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
M0M92_RS01870 (395115)	395115..395399	+	285	WP_044525202.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
M0M92_RS01875 (395403)	395403..395867	-	465	WP_012969085.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
M0M92_RS01880 (396263)	396263..398401	-	2139	WP_004206513.1	anaerobic ribonucleoside-triphosphate reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-70)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10965.82 Da
• Isoelectric Point: 10.4974

>T243016 WP_044525202.1 NZ_CP096263:395115-395399 [Klebsiella quasipneumoniae]
MTYELAFDPRAWREWHKLGETIKKQFKNKLQQVVQNPRIASASLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T243016 NZ_OW968288:c4121769-4121482 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9119.58 Da
• Isoelectric Point: 4.8146

>AT243016 WP_023291757.1 NZ_CP096263:394883-395125 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDSEAALLRTVRERLENPQPEVKVSLDDL

Nucleotide

• Length: 243 bp

>AT243016 NZ_OW968288:c4121495-4121193 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Structures

Antitoxin

• AlphaFold DB: A0A1C1EW86