Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 87248..88158 | Replicon | plasmid pKP19-2796-1 |
| Accession | NZ_CP096261 | ||
| Organism | Klebsiella pneumoniae strain KP19-2796 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | M0M88_RS26380 | Protein ID | WP_032413375.1 |
| Coordinates | 87688..88158 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A7H4PRG4 |
| Locus tag | M0M88_RS26375 | Protein ID | WP_032413443.1 |
| Coordinates | 87248..87691 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M0M88_RS26345 (M0M88_26345) | 82932..83603 | - | 672 | WP_159226239.1 | alpha/beta hydrolase | - |
| M0M88_RS26350 (M0M88_26350) | 83694..84662 | - | 969 | WP_077268726.1 | IS5-like element IS903B family transposase | - |
| M0M88_RS26355 (M0M88_26355) | 85078..85626 | + | 549 | WP_023320124.1 | GNAT family N-acetyltransferase | - |
| M0M88_RS26360 (M0M88_26360) | 85749..86330 | - | 582 | WP_077254766.1 | transposase | - |
| M0M88_RS26365 (M0M88_26365) | 86350..86535 | + | 186 | WP_071571073.1 | DUF2188 domain-containing protein | - |
| M0M88_RS26370 (M0M88_26370) | 86636..87148 | + | 513 | Protein_92 | DUF4113 domain-containing protein | - |
| M0M88_RS26375 (M0M88_26375) | 87248..87691 | + | 444 | WP_032413443.1 | DUF2384 domain-containing protein | Antitoxin |
| M0M88_RS26380 (M0M88_26380) | 87688..88158 | + | 471 | WP_032413375.1 | RES family NAD+ phosphorylase | Toxin |
| M0M88_RS26385 (M0M88_26385) | 88268..88528 | - | 261 | WP_017901409.1 | hypothetical protein | - |
| M0M88_RS26390 (M0M88_26390) | 89100..89477 | - | 378 | Protein_96 | integrase core domain-containing protein | - |
| M0M88_RS26395 (M0M88_26395) | 89551..89744 | + | 194 | Protein_97 | transposase | - |
| M0M88_RS26400 (M0M88_26400) | 89867..90817 | + | 951 | WP_077268727.1 | IS5-like element IS903B family transposase | - |
| M0M88_RS26405 (M0M88_26405) | 90828..91355 | + | 528 | WP_224707344.1 | hypothetical protein | - |
| M0M88_RS26410 (M0M88_26410) | 91296..91451 | - | 156 | Protein_100 | transposase | - |
| M0M88_RS26415 (M0M88_26415) | 92187..92279 | - | 93 | Protein_101 | hypothetical protein | - |
| M0M88_RS26420 (M0M88_26420) | 92330..92857 | + | 528 | WP_102004565.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | aph(3')-Ia / mph(E) / msr(E) / armA / sul1 / blaDHA-1 / qnrB4 / aadA2 / cmlA1 / ant(3'')-Ia / sul3 / aac(3)-IVa / aph(4)-Ia / aph(6)-Id / aph(3'')-Ib | - | 1..227518 | 227518 | |
| - | inside | IScluster/Tn | - | - | 79503..112324 | 32821 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17547.79 Da Isoelectric Point: 4.5152
>T243013 WP_032413375.1 NZ_CP096261:87688-88158 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIAFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIAFRFDSRLKPDRK
Download Length: 471 bp
>T243013 NZ_OW968288:3514282-3514500 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 148 a.a. Molecular weight: 16508.82 Da Isoelectric Point: 10.3013
>AT243013 WP_032413443.1 NZ_CP096261:87248-87691 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
>AT243013 NZ_OW968288:3513882-3514256 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|