Detailed information of TA system TA243011

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4971026..4972707
• Replicon: chromosome
• Accession: NZ_CP096260
• Organism: Klebsiella pneumoniae strain KP19-2796

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: M0M88_RS24040
• Protein ID: WP_004178299.1
• Coordinates: 4971026..4971943 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: M0M88_RS24045
• Protein ID: WP_004177809.1
• Coordinates: 4971949..4972707 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M0M88_RS24020 (4966332)	4966332..4967852	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
M0M88_RS24025 (4967849)	4967849..4968847	+	999	WP_002885172.1	ribose ABC transporter permease	-
M0M88_RS24030 (4968878)	4968878..4969819	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
M0M88_RS24035 (4969894)	4969894..4970901	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
M0M88_RS24040 (4971026)	4971026..4971943	-	918	WP_004178299.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
M0M88_RS24045 (4971949)	4971949..4972707	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
M0M88_RS24050 (4972865)	4972865..4974073	-	1209	WP_001339197.1	IS4-like element ISVsa5 family transposase	-
M0M88_RS24055 (4974143)	4974143..4974859	-	717	WP_248487476.1	response regulator transcription factor	-
M0M88_RS24060 (4975132)	4975132..4977279	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
M0M88_RS24065 (4977276)	4977276..4977419	-	144	WP_022631365.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	4972865..4974073	1208

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34649.06 Da
• Isoelectric Point: 5.4707

>T243011 WP_004178299.1 NZ_CP096260:c4971943-4971026 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T243011 NZ_OW968288:2703947-2704054 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT243011 WP_004177809.1 NZ_CP096260:c4972707-4971949 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT243011 NZ_OW968288:c2703900-2703834 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Antitoxin

• AlphaFold DB: A6TH05