Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4813992..4814508 Replicon chromosome
Accession NZ_CP096260
Organism Klebsiella pneumoniae strain KP19-2796

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag M0M88_RS23240 Protein ID WP_004178374.1
Coordinates 4813992..4814276 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M0M88_RS23245 Protein ID WP_002886901.1
Coordinates 4814266..4814508 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0M88_RS23215 (4809476) 4809476..4809739 - 264 WP_020324507.1 PTS system, lactose/cellobiose-specific IIB subunit -
M0M88_RS23220 (4809869) 4809869..4810042 + 174 WP_032408826.1 hypothetical protein -
M0M88_RS23225 (4810045) 4810045..4810788 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M0M88_RS23230 (4811145) 4811145..4813283 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M0M88_RS23235 (4813524) 4813524..4813988 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M0M88_RS23240 (4813992) 4813992..4814276 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M0M88_RS23245 (4814266) 4814266..4814508 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M0M88_RS23250 (4814586) 4814586..4816496 - 1911 WP_004178373.1 PRD domain-containing protein -
M0M88_RS23255 (4816519) 4816519..4817673 - 1155 WP_004178372.1 lactonase family protein -
M0M88_RS23260 (4817740) 4817740..4818480 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T243010 WP_004178374.1 NZ_CP096260:c4814276-4813992 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T243010 NZ_OW968288:c2490985-2490809 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT243010 WP_002886901.1 NZ_CP096260:c4814508-4814266 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT243010 NZ_OW968288:c2490763-2490347 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References