Detailed information of TA system TA243006

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2744254..2745842
• Replicon: chromosome
• Accession: NZ_CP096260
• Organism: Klebsiella pneumoniae strain KP19-2796

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: M0M88_RS13425
• Protein ID: WP_004179815.1
• Coordinates: 2744254..2745576 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: M0M88_RS13430
• Protein ID: WP_004176198.1
• Coordinates: 2745576..2745842 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M0M88_RS13410 (2739310)	2739310..2741811	+	2502	WP_020323802.1	fimbria/pilus outer membrane usher protein	-
M0M88_RS13415 (2741799)	2741799..2742803	+	1005	WP_004179822.1	fimbrial protein	-
M0M88_RS13420 (2742945)	2742945..2744237	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
M0M88_RS13425 (2744254)	2744254..2745576	-	1323	WP_004179815.1	type II toxin-antitoxin system HipA family toxin	Toxin
M0M88_RS13430 (2745576)	2745576..2745842	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
M0M88_RS13435 (2746108)	2746108..2746434	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
M0M88_RS13440 (2746431)	2746431..2746931	-	501	WP_004179811.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
M0M88_RS13445 (2746909)	2746909..2748288	-	1380	WP_004179808.1	nucleobase:cation symporter-2 family protein	-
M0M88_RS13450 (2748634)	2748634..2749788	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
M0M88_RS13455 (2749769)	2749769..2750692	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	mgtC / iroE	2528184..2780677	252493

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49152.42 Da
• Isoelectric Point: 7.2850

>T243006 WP_004179815.1 NZ_CP096260:c2745576-2744254 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T243006 NZ_OW968288:1794227-1794481 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT243006 WP_004176198.1 NZ_CP096260:c2745842-2745576 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT243006 NZ_OW968288:1793979-1794230 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA