Detailed information of TA system TA242996

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 783147..783948
• Replicon: chromosome
• Accession: NZ_CP096260
• Organism: Klebsiella pneumoniae strain KP19-2796

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: M0M88_RS03865
• Protein ID: WP_064143481.1
• Coordinates: 783147..783524 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: M0M88_RS03870
• Protein ID: WP_064143482.1
• Coordinates: 783571..783948 (-)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M0M88_RS03840 (779417)	779417..779861	+	445	Protein_755	integrase domain-containing protein	-
M0M88_RS03845 (780088)	780088..781326	-	1239	Protein_756	tyrosine-type recombinase/integrase	-
M0M88_RS03850 (781801)	781801..782643	-	843	WP_064143480.1	DUF4942 domain-containing protein	-
M0M88_RS03855 (782728)	782728..782925	-	198	WP_023563519.1	DUF957 domain-containing protein	-
M0M88_RS03860 (782953)	782953..783150	-	198	Protein_759	DUF5983 family protein	-
M0M88_RS03865 (783147)	783147..783524	-	378	WP_064143481.1	TA system toxin CbtA family protein	Toxin
M0M88_RS03870 (783571)	783571..783948	-	378	WP_064143482.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
M0M88_RS03875 (784028)	784028..784249	-	222	WP_000692312.1	DUF987 domain-containing protein	-
M0M88_RS03880 (784312)	784312..784788	-	477	WP_064143483.1	RadC family protein	-
M0M88_RS03885 (784804)	784804..785289	-	486	WP_000214414.1	antirestriction protein	-
M0M88_RS03890 (785381)	785381..786169	-	789	WP_064143484.1	DUF932 domain-containing protein	-
M0M88_RS03895 (786260)	786260..786493	-	234	WP_001117568.1	DUF905 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (19-117)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14037.93 Da
• Isoelectric Point: 7.2922

>T242996 WP_064143481.1 NZ_CP096260:c783524-783147 [Klebsiella pneumoniae]
MKTLPDTHEREASRCSSPVTIWQTLLARLLGQHYSLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
GTCAHSQLINSIDILRARRATGLLTRSNYRTVNDIIRGKDAEAKQ

Nucleotide

• Length: 378 bp

>T242996 NZ_OW968280:c4633684-4633427 [Klebsiella oxytoca]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCATATTCGCGATGCATC
AGGCCGCGTAACCTCTGTTGAATGCTATAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAACTCATTAAGTCCGTCAACGGGCAGCCCTACCGTATCAATACCACCGGGCTGAACAACGTTCGCGCT
CAGCTGGACAACCGCTAA

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 13751.48 Da
• Isoelectric Point: 5.4906

>AT242996 WP_064143482.1 NZ_CP096260:c783948-783571 [Klebsiella pneumoniae]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGQFSNADAYHLDQAFPLLLKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSWGYVYMAVYPTPAAPATTA

Nucleotide

• Length: 378 bp

>AT242996 NZ_OW968280:c4633416-4632865 [Klebsiella oxytoca]
ATGACAAACCATAACTTCACCTTTCACATCACCTCAGAGCGTGATGCTGATGATATTCGCGAAGTTGAAACCCGGGCCTT
CGGCTTTAGCAAAGAGGCCGATCTGGTTGCCGCTTTGCTCAACGATGAAAGTGCTCACCCGAGCTTATCTCTGCTGGCCA
AACATAATGGAAAAGCAGTTGGGCATATTTTGTTCACCCTGGCGACGTTCAAAGGGGAGTCTGACTCTCCGATGATGCAT
ATCCTTGCCCCTCTGGCGGTGGTGCCGGAATACCAGGGCATGGGTGTTGGCGGATTACTTATCCAAAGCGGTATTGAGCA
TCTGAAGGCAATGGGGAGCCTGGCGGTATTCGTTCTGGGACATGCCACTTATTACCCGCGGCATGGCTTTGAACCCTGTG
CCGGAGATAAAGGCTATCCGGCGCCTTATCCCATTCCCGAGGAGCATAAAGCCTGCTGGATGCTGCAGCGGCTTTCGTCC
CGGCCGCTGGGGATAACCGGTCAGATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA