Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 698013..698692 Replicon chromosome
Accession NZ_CP096260
Organism Klebsiella pneumoniae strain KP19-2796

Toxin (Protein)


Gene name ykfI Uniprot ID A0A0C7K7A4
Locus tag M0M88_RS03430 Protein ID WP_020324801.1
Coordinates 698351..698692 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0C7KEL2
Locus tag M0M88_RS03425 Protein ID WP_020324792.1
Coordinates 698013..698330 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0M88_RS03400 (693227) 693227..696379 + 3153 WP_022631414.1 AIDA repeat-containing protein -
M0M88_RS03405 (696472) 696472..696711 + 240 WP_020324820.1 DUF905 domain-containing protein -
M0M88_RS03410 (696814) 696814..697272 + 459 WP_020324813.1 antirestriction protein -
M0M88_RS03415 (697288) 697288..697764 + 477 WP_020324797.1 RadC family protein -
M0M88_RS03420 (697773) 697773..698000 + 228 WP_020324796.1 DUF987 domain-containing protein -
M0M88_RS03425 (698013) 698013..698330 + 318 WP_020324792.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
M0M88_RS03430 (698351) 698351..698692 + 342 WP_020324801.1 TA system toxin CbtA family protein Toxin
M0M88_RS03435 (698808) 698808..699641 + 834 WP_020324805.1 DUF4942 domain-containing protein -
M0M88_RS03445 (699944) 699944..700450 + 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
M0M88_RS03450 (700550) 700550..702391 - 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 675544..704355 28811


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(5-103)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12818.91 Da        Isoelectric Point: 9.1484

>T242995 WP_020324801.1 NZ_CP096260:698351-698692 [Klebsiella pneumoniae]
MKTLPAIISRAAKPCLSPVAVWQMLLTRLLEKHYGLTLNDTPFCDETVIQEHIDAGITLADAVNFLVEKYGLVRIDRNGF
VWQEQSPYLRAVDILRARQATGLLRQSRNNAIR

Download         Length: 342 bp

>T242995 NZ_OW968280:4396907-4397125 [Klebsiella oxytoca]
ATGTCTGATAAAACATTAACCAAAATAGACTATTTGATGCGCTTACGACGTTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAAAATAAATATGAACTTTCTGATAATGAACTGGCGGTATTTTACTCAGCAGCCGATCATCGTCTTGCTGAAC
TGACGATGAATAAACTGTATGACAAGATCCCGCCATCGGTCTGGAAATTCATCCGCTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11915.51 Da        Isoelectric Point: 6.6246

>AT242995 WP_020324792.1 NZ_CP096260:698013-698330 [Klebsiella pneumoniae]
MSNITWGLQRDTTPRLGARLVQEGNQLHYLADRASMTGKFSDAECRKLDETFPHFISQMESMLITGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAVYPIQR

Download         Length: 318 bp

>AT242995 NZ_OW968280:4396506-4396880 [Klebsiella oxytoca]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTTAATGACCCAACCTCTGCTGTCAATCTTCAGCTTAATGAATTGATCGAGC
ACATTGCCGCGTTCGCACTTAATTATAAAATTAAGTATGCTGAGGATAATAAGCTGGTGACTCAGCTTGACGAATATCTG
GATGACACTTTCGTGTTGTTCAGCAACTACGGCATTAACACTGCAGATCTGCAGAAATGGCGTAAATCAGGCAACAGGTT
ATTCCGCTGCTTTGTGAACGCCAGTCGGGAAAACCCGGCCAGTCTTTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7K7A4

Antitoxin

Source ID Structure
AlphaFold DB A0A0C7KEL2

References