Detailed information of TA system TA242992

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 4454138..4455494
• Replicon: chromosome
• Accession: NZ_CP096258
• Organism: Providencia rettgeri strain Pre20-95

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: M0M83_RS20510
• Protein ID: WP_248467294.1
• Coordinates: 4454529..4455494 (+)
• Length: 322 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: -
• Locus tag: M0M83_RS20505
• Protein ID: WP_125893772.1
• Coordinates: 4454138..4454542 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M0M83_RS20495 (M0M83_20500)	4449924..4452971	-	3048	WP_282561397.1	formate dehydrogenase-N subunit alpha	-
M0M83_RS20500 (M0M83_20505)	4453146..4453976	+	831	WP_213913812.1	formate dehydrogenase accessory sulfurtransferase FdhD	-
M0M83_RS20505 (M0M83_20510)	4454138..4454542	+	405	WP_125893772.1	DUF6088 family protein	Antitoxin
M0M83_RS20510 (M0M83_20515)	4454529..4455494	+	966	WP_248467294.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
M0M83_RS20515 (M0M83_20520)	4455741..4456775	+	1035	WP_001143643.1	DUF4365 domain-containing protein	-
M0M83_RS20520 (M0M83_20525)	4456888..4456980	+	93	Protein_3980	hypothetical protein	-
M0M83_RS20525 (M0M83_20530)	4457120..4457884	-	765	WP_001389365.1	IS6-like element IS6100 family transposase	-
M0M83_RS20535 (M0M83_20540)	4458391..4458891	-	501	WP_000376623.1	GNAT family N-acetyltransferase	-
M0M83_RS20540 (M0M83_20545)	4459019..4459858	-	840	WP_000259031.1	sulfonamide-resistant dihydropteroate synthase Sul1	-
M0M83_RS20545 (M0M83_20550)	4459852..4460199	-	348	WP_000679427.1	quaternary ammonium compound efflux SMR transporter QacE delta 1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (39-300)

Antitoxin

• Protein of unknown function DUF6088 (6-131)

Sequences

Toxin

Protein

• Length: 322 a.a.
• Molecular weight: 37189.49 Da
• Isoelectric Point: 5.2750

>T242992 WP_248467294.1 NZ_CP096258:4454529-4455494 [Providencia rettgeri]
MKLDSSLFIDVADAIGLGNPAIVEKDYYVVQLLKLLSNFQFTYHQAIFSGGTALAKSDIKTYRMSEDIDIKLIPNQRYLE
LASRNARKTARKEIKKIIEEIINQNPIFSLDNAPSVKDEYRYFSFDIRYPQDHRQVPCLRPFIKLEFIETDLLSEPISRN
IQSIYSNVTESDIEIYNMICSAIIDTQAEKLLSMLRRTASVARNGQREDDETLIRHVYDTFHIQLSQPSNIEFLSQLLKK
ALDGDITRYGNQHTQLVDSPITELRYGLKLLVETPKFIERYNNYVSPMVYAEVPIQWDEAIIAFTNLANQVLDYIEQKLN
K

Nucleotide

• Length: 966 bp

>T242992 NZ_OW968280:865044-865454 [Klebsiella oxytoca]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCGTGGCGAGCGCAATGGTTCTCACTGTTGATGCACGGCGTGGTGGCGGC
GCTGGTGCTGGTGTTGCCCTGGCCGCTGAGCTATACCCCGCTGTGGCTGATACTGCTGTCGCTGGTGGTGTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCAGACAGGGGGAAATAAAGCTGCTGATTGACTCTCGCCTGCGCTGGCAAAAAGCG
GAGTGGGATATCGTCGGCACCCCGTGGGTAATCAATAGCGGAATGCTGCTGCGCCTGAGAAATACGGAAAACCAACGCAC
TCAGCATCTATGGGTGGCGGCGGATAGCATGGACGCGGGCGAGTGGCGCGATCTGCGTCGGCTGGTGTTACAGAAACCGA
CGCAAGATTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 15333.04 Da
• Isoelectric Point: 11.1248

>AT242992 WP_125893772.1 NZ_CP096258:4454138-4454542 [Providencia rettgeri]
MTIQDRIQKKVKRSRRSVFLRSDFSKIADYDQVGRILKKLTDNGLLMRIGYGVYVRARVNRITGKLMPDNPSGADGVIIE
VMKKLNVDYTFDKLSMMNLSGESTQIPSNIKIIPKNPKFTRKIKVGKQSINETR

Nucleotide

• Length: 405 bp

>AT242992 NZ_OW968280:864797-865063 [Klebsiella oxytoca]
ATGGATATTAACAATAAAGCTCGCATCCACTGGGCATGCCGCCGGGGAATGCGTGAACTCGATATCTCCATCATGCCGTT
TTTTGAGCATGAGTACGATACGCTCAGTGATGACGATAAGCGGTTGTTCATCCGCCTGCTGGAAAATGACGATCCGGACC
TGTTCAACTGGTTGATGAACCATGGCGAACCGGCTGATGCAGAACTGCAGCGGATGGTAAAATTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA