Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 4334201..4334784 Replicon chromosome
Accession NZ_CP096258
Organism Providencia rettgeri strain Pre20-95

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag M0M83_RS19915 Protein ID WP_125893514.1
Coordinates 4334482..4334784 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag M0M83_RS19910 Protein ID WP_248467241.1
Coordinates 4334201..4334485 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0M83_RS19890 (M0M83_19895) 4329308..4330321 - 1014 WP_248467239.1 sulfate ABC transporter substrate-binding protein -
M0M83_RS19895 (M0M83_19900) 4330702..4331679 - 978 WP_125893508.1 6-phosphofructokinase -
M0M83_RS19900 (M0M83_19905) 4332571..4333323 - 753 WP_125893510.1 M48 family metallopeptidase -
M0M83_RS19905 (M0M83_19910) 4333536..4334117 - 582 WP_248467240.1 HutD family protein -
M0M83_RS19910 (M0M83_19915) 4334201..4334485 - 285 WP_248467241.1 putative addiction module antidote protein Antitoxin
M0M83_RS19915 (M0M83_19920) 4334482..4334784 - 303 WP_125893514.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M0M83_RS19920 (M0M83_19925) 4335042..4335392 - 351 WP_282561391.1 Spy/CpxP family protein refolding chaperone -
M0M83_RS19925 (M0M83_19930) 4335358..4335600 - 243 WP_248467243.1 hypothetical protein -
M0M83_RS19930 (M0M83_19935) 4335751..4336449 + 699 WP_004265224.1 envelope stress response regulator transcription factor CpxR -
M0M83_RS19935 (M0M83_19940) 4336446..4337816 + 1371 WP_125893565.1 envelope stress sensor histidine kinase CpxA -
M0M83_RS19940 (M0M83_19945) 4338296..4339732 + 1437 WP_248467244.1 capsule assembly Wzi family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(45-90)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11401.31 Da        Isoelectric Point: 10.0723

>T242991 WP_125893514.1 NZ_CP096258:c4334784-4334482 [Providencia rettgeri]
MITVLTTECFDSWIKNLRDIRAKTKILVRIRRLKNGNYGDVQPIGDGFSELRVHEGQGYRVYLKQKNNVIVILLCGGTKA
TQQKDIHKAKLLFGEVEGEL

Download         Length: 303 bp

>T242991 NZ_OW968278:98046-98351 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCTGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGTTGTCAGATAAGGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAGGAAGTG
GCTGATCTCAGCCACCGAGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10484.15 Da        Isoelectric Point: 4.5983

>AT242991 WP_248467241.1 NZ_CP096258:c4334485-4334201 [Providencia rettgeri]
MNTKLKEFDITEYLNSEEEIQMYLNEILEEGDPSLVLAALGDIAKARNMSQLAKEVGMSREGLYKALSGQGNPTFMTIIK
IVNSLGLKLQFKSI

Download         Length: 285 bp

>AT242991 NZ_OW968278:97826-98044 [Escherichia coli]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGGCT
GGTAAGCACCACCCTGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCAGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References