Detailed information of TA system TA242987

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3074453..3075110
• Replicon: chromosome
• Accession: NZ_CP096258
• Organism: Providencia rettgeri strain Pre20-95

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: M0M83_RS14050
• Protein ID: WP_213914557.1
• Coordinates: 3074453..3074863 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: D4C097
• Locus tag: M0M83_RS14055
• Protein ID: WP_004261864.1
• Coordinates: 3074844..3075110 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M0M83_RS14030 (M0M83_14035)	3070337..3072007	-	1671	WP_248468455.1	single-stranded-DNA-specific exonuclease RecJ	-
M0M83_RS14035 (M0M83_14040)	3072080..3072784	-	705	WP_248466785.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
M0M83_RS14040 (M0M83_14045)	3072806..3073708	-	903	WP_109912915.1	site-specific tyrosine recombinase XerD	-
M0M83_RS14045 (M0M83_14050)	3073826..3074344	+	519	WP_125894089.1	flavodoxin FldB	-
M0M83_RS14050 (M0M83_14055)	3074453..3074863	-	411	WP_213914557.1	protein YgfX	Toxin
M0M83_RS14055 (M0M83_14060)	3074844..3075110	-	267	WP_004261864.1	FAD assembly factor SdhE	Antitoxin
M0M83_RS14060 (M0M83_14065)	3075358..3076341	+	984	WP_125894094.1	tRNA-modifying protein YgfZ	-
M0M83_RS14065 (M0M83_14070)	3076353..3076973	+	621	WP_125894096.1	HD domain-containing protein	-
M0M83_RS14070 (M0M83_14075)	3077214..3078110	+	897	WP_248466786.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-133)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15581.48 Da
• Isoelectric Point: 10.5599

>T242987 WP_213914557.1 NZ_CP096258:c3074863-3074453 [Providencia rettgeri]
VVLWKSNLSISWKTQLFSTCVHGVVGMILLLTPWSPENSMIWLPLLVVVVASWAKSQKTISKIKGVAVLVNGNKVQWKKN
EWRILKAPWLSRYGTLLTLEALQGKPQKVYLWVAKDALSEDNWRNLNQLLLQYPDI

Nucleotide

• Length: 411 bp

>T242987 NZ_OW968277:3953227-3953634 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10684.24 Da
• Isoelectric Point: 4.8942

>AT242987 WP_004261864.1 NZ_CP096258:c3075110-3074844 [Providencia rettgeri]
MDIENKARIHWACRRGMRELDISIMPFFEYEYDDLTTHDKQVFVRLLECADPDLFNWLMNHGRPDDDELFRMIKLIQEKN
KNRGPVEI

Nucleotide

• Length: 267 bp

>AT242987 NZ_OW968277:3952980-3953246 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A345M2Q5