Detailed information of TA system TA242986

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2246691..2247607
• Replicon: chromosome
• Accession: NZ_CP096258
• Organism: Providencia rettgeri strain Pre20-95

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: M0M83_RS10330
• Protein ID: WP_213912746.1
• Coordinates: 2246691..2247149 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: M0M83_RS10335
• Protein ID: WP_248466530.1
• Coordinates: 2247146..2247607 (-)
• Length: 154 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M0M83_RS10305 (M0M83_10310)	2242230..2243696	+	1467	WP_213912751.1	AMP nucleosidase	-
M0M83_RS10310 (M0M83_10315)	2243704..2244240	+	537	WP_248468445.1	GNAT family N-acetyltransferase	-
M0M83_RS10315 (M0M83_10320)	2244271..2244609	+	339	WP_248468405.1	MerR family transcriptional regulator	-
M0M83_RS10320 (M0M83_10325)	2244799..2245758	+	960	WP_213912748.1	acetyl-CoA carboxylase carboxyl transferase subunit alpha	-
M0M83_RS10325 (M0M83_10330)	2245800..2246690	+	891	WP_248468406.1	LysR family transcriptional regulator	-
M0M83_RS10330 (M0M83_10335)	2246691..2247149	-	459	WP_213912746.1	RES domain-containing protein	Toxin
M0M83_RS10335 (M0M83_10340)	2247146..2247607	-	462	WP_248466530.1	DUF2384 domain-containing protein	Antitoxin
M0M83_RS10340 (M0M83_10345)	2247694..2248161	-	468	WP_125894493.1	DUF1456 family protein	-
M0M83_RS10345 (M0M83_10350)	2248349..2248663	-	315	WP_125894496.1	AzlD domain-containing protein	-
M0M83_RS10350 (M0M83_10355)	2248660..2249361	-	702	WP_248466531.1	AzlC family ABC transporter permease	-
M0M83_RS10355 (M0M83_10360)	2249826..2250467	+	642	WP_213912743.1	leucine efflux protein LeuE	-
M0M83_RS10360 (M0M83_10365)	2250746..2251219	+	474	WP_248466532.1	NUDIX domain-containing protein	-
M0M83_RS10365 (M0M83_10370)	2251243..2251857	-	615	WP_213912741.1	LysE family translocator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-145)

Antitoxin

• Antitoxin Xre (20-153)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17164.75 Da
• Isoelectric Point: 5.9497

>T242986 WP_213912746.1 NZ_CP096258:c2247149-2246691 [Providencia rettgeri]
MILYRLVKSSFVHDAWSGQGAMLYGGRWNHKGTPAVYTSTSISLATLEILVHINQDILLNQFSLLSIDINDKYVMKLSLD
HLPTDWQQDPAPTSTMDIGTTWLNNQDSLVLLIPSCIIPYEYNAILNPLHPQFQKAIQTVKPLDFNVDPRLA

Nucleotide

• Length: 459 bp

>T242986 NZ_OW968277:c3808264-3807887 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin

Protein

• Length: 154 a.a.
• Molecular weight: 17028.48 Da
• Isoelectric Point: 9.7275

>AT242986 WP_248466530.1 NZ_CP096258:c2247607-2247146 [Providencia rettgeri]
MRNYIPTTPIQPAASAFKPLWRHVGLPAERGIELTHYLRQGLSVSVLDNIQEWSGVSKTELLRISGINERNIARRKNAGQ
PLNADESERIARLVRVFDAAVRLFNGDKHAASDWLNHPVKGLGHLRPIELIATESGAIEVIDLIGRIEHGVFS

Nucleotide

• Length: 462 bp

>AT242986 NZ_OW968277:c3808721-3808353 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCTGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGTACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACCGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGACTGACCTGCGAAGCCGATACCCTGGGCTCCTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA