Detailed information of TA system TA242985

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/COG3657-dnstrm_HI1420
• Location: 1962423..1963017
• Replicon: chromosome
• Accession: NZ_CP096258
• Organism: Providencia rettgeri strain Pre20-95

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: M0M83_RS09005
• Protein ID: WP_248468298.1
• Coordinates: 1962423..1962737 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: M0M83_RS09010
• Protein ID: WP_117162001.1
• Coordinates: 1962730..1963017 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M0M83_RS08980 (M0M83_08980)	1958005..1960392	+	2388	WP_248468292.1	phenylalanine--tRNA ligase subunit beta	-
M0M83_RS08985 (M0M83_08985)	1960397..1960693	+	297	WP_004263721.1	integration host factor subunit alpha	-
M0M83_RS08990 (M0M83_08990)	1960906..1961556	+	651	WP_248468294.1	DCL family protein	-
M0M83_RS08995 (M0M83_08995)	1961604..1961822	-	219	WP_248468296.1	ogr/Delta-like zinc finger family protein	-
M0M83_RS09000 (M0M83_09000)	1961894..1962241	-	348	Protein_1737	contractile injection system protein, VgrG/Pvc8 family	-
M0M83_RS09005 (M0M83_09005)	1962423..1962737	+	315	WP_248468298.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
M0M83_RS09010 (M0M83_09010)	1962730..1963017	+	288	WP_117162001.1	putative addiction module antidote protein	Antitoxin
M0M83_RS09015 (M0M83_09015)	1963201..1964205	-	1005	WP_282561467.1	hypothetical protein	-
M0M83_RS09020 (M0M83_09020)	1964328..1965329	+	1002	WP_248468302.1	vitamin B12 ABC transporter permease BtuC	-
M0M83_RS09025 (M0M83_09025)	1965332..1966108	+	777	WP_248468304.1	ATP-binding cassette domain-containing protein	-
M0M83_RS09030 (M0M83_09030)	1966228..1967373	+	1146	WP_213913267.1	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1960397..1971243	10846

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (1-95)

Antitoxin

• Uncharacterized protein HI1420 (4-90)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11843.67 Da
• Isoelectric Point: 10.0007

>T242985 WP_248468298.1 NZ_CP096258:1962423-1962737 [Providencia rettgeri]
MKELKQTDAFRLWESKLKDKRARTMIATRLFRLANGLAGDAMPVGEGISELRIHYGPGYRVYYQQRGNTIILLLCGGDKG
SQSRDITLAKTLAKKWILEENNDE

Nucleotide

• Length: 315 bp

>T242985 NZ_OW968277:3642660-3642974 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10155.55 Da
• Isoelectric Point: 4.3855

>AT242985 WP_117162001.1 NZ_CP096258:1962730-1963017 [Providencia rettgeri]
MSNLTTYDPALALVDDEEIAFFMADAIETGDSAYIAKALGIVARAKGMSQIAAETGLSREQLYRSFSEDGNPTLKSTLAV
MKALGVELTVKTHVN

Nucleotide

• Length: 288 bp

>AT242985 NZ_OW968277:3642971-3643387 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA