Detailed information of TA system TA242984

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 1764724..1765271
• Replicon: chromosome
• Accession: NZ_CP096258
• Organism: Providencia rettgeri strain Pre20-95

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: M0M83_RS08025
• Protein ID: WP_248468158.1
• Coordinates: 1764724..1765032 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: M0M83_RS08030
• Protein ID: WP_248468160.1
• Coordinates: 1765032..1765271 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M0M83_RS07995 (M0M83_07995)	1760706..1761542	+	837	WP_248468433.1	CheR family methyltransferase	-
M0M83_RS08000 (M0M83_08000)	1761542..1762609	+	1068	WP_248468154.1	chemotaxis response regulator protein-glutamate methylesterase	-
M0M83_RS08005 (M0M83_08005)	1762651..1763043	+	393	WP_034782834.1	chemotaxis response regulator CheY	-
M0M83_RS08010 (M0M83_08010)	1763068..1763706	+	639	WP_248468155.1	protein phosphatase CheZ	-
M0M83_RS08015 (M0M83_08015)	1763794..1764099	+	306	WP_125890798.1	helix-turn-helix transcriptional regulator	-
M0M83_RS08020 (M0M83_08020)	1764151..1764708	-	558	WP_248468156.1	hypothetical protein	-
M0M83_RS08025 (M0M83_08025)	1764724..1765032	-	309	WP_248468158.1	CcdB family protein	Toxin
M0M83_RS08030 (M0M83_08030)	1765032..1765271	-	240	WP_248468160.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
M0M83_RS08035 (M0M83_08035)	1765535..1766686	+	1152	WP_248468162.1	flagellar biosynthesis protein FlhB	-
M0M83_RS08040 (M0M83_08040)	1766679..1768778	+	2100	WP_213914081.1	flagellar biosynthesis protein FlhA	-
M0M83_RS08045 (M0M83_08045)	1768971..1769291	+	321	WP_248468164.1	helix-turn-helix domain-containing protein	-
M0M83_RS08050 (M0M83_08050)	1769336..1769776	-	441	WP_248468166.1	flagellar export chaperone FlgN	-
M0M83_RS08055 (M0M83_08055)	1769786..1770088	-	303	WP_248468168.1	flagellar biosynthesis anti-sigma factor FlgM	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-101)

Antitoxin

• Post-segregation antitoxin CcdA (9-79)

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11794.95 Da
• Isoelectric Point: 7.8789

>T242984 WP_248468158.1 NZ_CP096258:c1765032-1764724 [Providencia rettgeri]
MQYCLYQNRDDAIKYSYLLDIQSNIIDILNTRLVIPLFDSRLVKKPLPARLNPQLVINGQFFILMTHQMACVPLSLLGKE
IVDLTHQRDTIKHAIDLLINGF

Nucleotide

• Length: 309 bp

>T242984 NZ_OW968277:c3602597-3602133 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9116.44 Da
• Isoelectric Point: 8.9266

>AT242984 WP_248468160.1 NZ_CP096258:c1765271-1765032 [Providencia rettgeri]
MSTTAQRMKKTVSVTITPELYEQARKAKLNFSAVLACALQAELKRLEAQKWKSENIDGFNELNRINEEYGLLSDKYKDF

Nucleotide

• Length: 240 bp

>AT242984 NZ_OW968277:c3602932-3602597 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAT
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA