Detailed information of TA system TA242983

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1001196..1001842
• Replicon: chromosome
• Accession: NZ_CP096258
• Organism: Providencia rettgeri strain Pre20-95

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: -
• Locus tag: M0M83_RS04275
• Protein ID: WP_102139052.1
• Coordinates: 1001196..1001399 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: M0M83_RS04280
• Protein ID: WP_125891994.1
• Coordinates: 1001474..1001842 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M0M83_RS04250 (M0M83_04250)	997274..997612	+	339	WP_125891991.1	P-II family nitrogen regulator	-
M0M83_RS04255 (M0M83_04255)	997662..998909	+	1248	WP_213913015.1	ammonium transporter AmtB	-
M0M83_RS04260 (M0M83_04260)	999050..999919	-	870	WP_248467684.1	acyl-CoA thioesterase II	-
M0M83_RS04265 (M0M83_04265)	1000159..1000617	+	459	WP_125891993.1	YbaY family lipoprotein	-
M0M83_RS04275 (M0M83_04275)	1001196..1001399	-	204	WP_102139052.1	HHA domain-containing protein	Toxin
M0M83_RS04280 (M0M83_04280)	1001474..1001842	-	369	WP_125891994.1	Hha toxicity modulator TomB	Antitoxin
M0M83_RS04285 (M0M83_04285)	1002368..1003738	-	1371	WP_125891995.1	murein transglycosylase D	-
M0M83_RS04290 (M0M83_04290)	1003820..1004575	-	756	WP_248467686.1	hydroxyacylglutathione hydrolase	-
M0M83_RS04295 (M0M83_04295)	1004616..1005350	+	735	WP_125891997.1	methyltransferase domain-containing protein	-
M0M83_RS04300 (M0M83_04300)	1005347..1005817	-	471	WP_125891999.1	ribonuclease HI	-
M0M83_RS04305 (M0M83_04305)	1005872..1006633	+	762	WP_125892002.1	DNA polymerase III subunit epsilon	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	aac(3)-IId	fimA	705524..1002186	296662

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-117)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8121.44 Da
• Isoelectric Point: 6.9770

>T242983 WP_102139052.1 NZ_CP096258:c1001399-1001196 [Providencia rettgeri]
MTKFDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Nucleotide

• Length: 204 bp

>T242983 NZ_OW968277:3291154-3291681 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 14048.02 Da
• Isoelectric Point: 4.3945

>AT242983 WP_125891994.1 NZ_CP096258:c1001842-1001474 [Providencia rettgeri]
MDEYSPKKHDIAELKYLCNSLNREAILSLQKTNTHWVNDLSSPQSAALNELIEHIAAFVWRFKIKYPKENLVISLIEEYL
DETYDLFGSPVITLSEIIDWEAMNQSLVTVLDDDLKCLASKT

Nucleotide

• Length: 369 bp

>AT242983 NZ_OW968277:3290881-3291147 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA