Detailed information of TA system TA242982

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 783811..785533
• Replicon: chromosome
• Accession: NZ_CP096258
• Organism: Providencia rettgeri strain Pre20-95

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: M0M83_RS03325
• Protein ID: WP_248467602.1
• Coordinates: 784595..785533 (+)
• Length: 313 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: M0M83_RS03320
• Protein ID: WP_001896349.1
• Coordinates: 783811..784602 (+)
• Length: 264 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M0M83_RS03285 (M0M83_03285)	778980..779207	-	228	WP_282561481.1	type II toxin-antitoxin system RelE/ParE family toxin	-
M0M83_RS03290 (M0M83_03290)	779484..779765	+	282	WP_000433891.1	type IV conjugative transfer system protein TraL	-
M0M83_RS03295 (M0M83_03295)	779762..780388	+	627	WP_028870242.1	TraE/TraK family type IV conjugative transfer system protein	-
M0M83_RS03300 (M0M83_03300)	780372..781268	+	897	WP_248468412.1	type-F conjugative transfer system secretin TraK	-
M0M83_RS03305 (M0M83_03305)	781271..782560	+	1290	WP_008844783.1	TraB/VirB10 family protein	-
M0M83_RS03310 (M0M83_03310)	782779..783207	+	429	WP_282561482.1	TraV family lipoprotein	-
M0M83_RS03315 (M0M83_03315)	783204..783590	+	387	WP_248467601.1	TraA family conjugative transfer protein	-
M0M83_RS03320 (M0M83_03320)	783811..784602	+	792	WP_001896349.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
M0M83_RS03325 (M0M83_03325)	784595..785533	+	939	WP_248467602.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
M0M83_RS21460	785691..785876	+	186	WP_282561418.1	hypothetical protein	-
M0M83_RS03330 (M0M83_03330)	786057..786713	-	657	WP_025611037.1	hypothetical protein	-
M0M83_RS03335 (M0M83_03335)	786757..786903	-	147	WP_248467604.1	hypothetical protein	-
M0M83_RS03340 (M0M83_03340)	787145..787837	+	693	WP_248467606.1	DsbC family protein	-
M0M83_RS03345 (M0M83_03345)	787837..790236	+	2400	WP_248467608.1	type IV secretion system protein TraC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	aac(3)-IId	fimA	705524..1002186	296662

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (99-250)

Sequences

Toxin

Protein

• Length: 313 a.a.
• Molecular weight: 35482.76 Da
• Isoelectric Point: 4.9960

>T242982 WP_248467602.1 NZ_CP096258:784595-785533 [Providencia rettgeri]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDKINTQ
PDIRAAFQDNKADELRIVVSSPFATIKIEVSPVARGTLHSAEIMPVQASVEDEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGISREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLIELQK
HFTERDHAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLANANAE

Nucleotide

• Length: 939 bp

>T242982 NZ_OW968277:3188656-3188763 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAGCTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 264 a.a.
• Molecular weight: 30099.46 Da
• Isoelectric Point: 9.5097

>AT242982 WP_001896349.1 NZ_CP096258:783811-784602 [Providencia rettgeri]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVSVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG

Nucleotide

• Length: 792 bp

>AT242982 NZ_OW968277:c3188599-3188542 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT