Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4912787..4913303 Replicon chromosome
Accession NZ_CP096242
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD01665

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag M0535_RS23630 Protein ID WP_004178374.1
Coordinates 4912787..4913071 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M0535_RS23635 Protein ID WP_002886901.1
Coordinates 4913061..4913303 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0535_RS23605 (4908183) 4908183..4908446 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
M0535_RS23610 (4908576) 4908576..4908749 + 174 WP_041169004.1 hypothetical protein -
M0535_RS23615 (4908752) 4908752..4909495 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M0535_RS23620 (4909852) 4909852..4911990 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M0535_RS23625 (4912319) 4912319..4912783 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M0535_RS23630 (4912787) 4912787..4913071 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M0535_RS23635 (4913061) 4913061..4913303 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M0535_RS23640 (4913381) 4913381..4915291 - 1911 WP_012737231.1 PRD domain-containing protein -
M0535_RS23645 (4915314) 4915314..4916468 - 1155 WP_012737230.1 lactonase family protein -
M0535_RS23650 (4916535) 4916535..4917275 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T242969 WP_004178374.1 NZ_CP096242:c4913071-4912787 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T242969 NZ_OW968277:c845926-845672 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAGCAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAACTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCTTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT242969 WP_002886901.1 NZ_CP096242:c4913303-4913061 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT242969 NZ_OW968277:c846174-845923 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGACAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References