Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4983048..4983564 Replicon chromosome
Accession NZ_CP096238
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD02201

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag M0536_RS24070 Protein ID WP_004178374.1
Coordinates 4983048..4983332 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag M0536_RS24075 Protein ID WP_002886901.1
Coordinates 4983322..4983564 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0536_RS24045 (4978444) 4978444..4978707 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
M0536_RS24050 (4978837) 4978837..4979010 + 174 WP_041169004.1 hypothetical protein -
M0536_RS24055 (4979013) 4979013..4979756 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
M0536_RS24060 (4980113) 4980113..4982251 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
M0536_RS24065 (4982580) 4982580..4983044 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
M0536_RS24070 (4983048) 4983048..4983332 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M0536_RS24075 (4983322) 4983322..4983564 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
M0536_RS24080 (4983642) 4983642..4985552 - 1911 WP_012737231.1 PRD domain-containing protein -
M0536_RS24085 (4985575) 4985575..4986729 - 1155 WP_012737230.1 lactonase family protein -
M0536_RS24090 (4986796) 4986796..4987536 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T242949 WP_004178374.1 NZ_CP096238:c4983332-4983048 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T242949 NZ_OW968124:1795166-1795420 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT242949 WP_002886901.1 NZ_CP096238:c4983564-4983322 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT242949 NZ_OW968124:1794918-1795169 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References