Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2784102..2785690 Replicon chromosome
Accession NZ_CP096238
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD02201

Toxin (Protein)


Gene name hipA Uniprot ID A0A331XLA5
Locus tag M0536_RS13540 Protein ID WP_014907613.1
Coordinates 2784102..2785424 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag M0536_RS13545 Protein ID WP_002904790.1
Coordinates 2785424..2785690 (-) Length 89 a.a.

Genomic Context


M0536_RS13525M0536_RS13530M0536_RS13535M0536_RS13565M0536_RS13540M0536_RS13545M0536_RS13550M0536_RS13555M0536_RS13560M0536_RS13570
Location: 2779158..2781659 (2502 bp)
Type: Others
Protein ID: WP_014907611.1
Location: 2781647..2782651 (1005 bp)
Type: Others
Protein ID: WP_270104270.1
Location: 2782793..2784085 (1293 bp)
Type: Others
Protein ID: WP_002904794.1
Location: 2788454..2789608 (1155 bp)
Type: Others
Protein ID: WP_002904783.1
Location: 2784102..2785424 (1323 bp)
Type: Toxin
Protein ID: WP_014907613.1
Location: 2785424..2785690 (267 bp)
Type: Antitoxin
Protein ID: WP_002904790.1
Location: 2785928..2786254 (327 bp)
Type: Others
Protein ID: WP_004215084.1
Location: 2786251..2786751 (501 bp)
Type: Others
Protein ID: WP_004184022.1
Location: 2786729..2788108 (1380 bp)
Type: Others
Protein ID: WP_004184021.1
Location: 2789589..2790512 (924 bp)
Type: Others
Protein ID: WP_002904781.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
M0536_RS13525 (2779158)2779158..2781659+2502WP_014907611.1fimbria/pilus outer membrane usher protein-
M0536_RS13530 (2781647)2781647..2782651+1005WP_270104270.1fimbrial protein-
M0536_RS13535 (2782793)2782793..2784085+1293WP_002904794.1glycoside hydrolase family 10 protein-
M0536_RS13540 (2784102)2784102..2785424-1323WP_014907613.1type II toxin-antitoxin system HipA family toxinToxin
M0536_RS13545 (2785424)2785424..2785690-267WP_002904790.1type II toxin-antitoxin system antitoxin HipBAntitoxin
M0536_RS13550 (2785928)2785928..2786254-327WP_004215084.1hydroxyisourate hydrolase-
M0536_RS13555 (2786251)2786251..2786751-501WP_004184022.12-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase-
M0536_RS13560 (2786729)2786729..2788108-1380WP_004184021.1nucleobase:cation symporter-2 family protein-
M0536_RS13565 (2788454)2788454..2789608+1155WP_002904783.1FAD-dependent urate hydroxylase HpxO-
M0536_RS13570 (2789589)2789589..2790512-924WP_002904781.1LysR family hpxDE operon transcriptional regulator HpxR-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-103)

Antitoxin

(16-65)


Sequences


Toxin        


Download         Length: 441 a.a.        Molecular weight: 49139.47 Da        Isoelectric Point: 7.5367

>T242947 WP_014907613.1 NZ_CP096238:c2785424-2784102 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T242947 NZ_OW968124:999950-1000285 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT242947 WP_002904790.1 NZ_CP096238:c2785690-2785424 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT242947 NZ_OW968124:999702-999950 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A331XLA5


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3GXD8

References