Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 103384..104294 Replicon plasmid pVirDD02357
Accession NZ_CP096235
Organism Klebsiella pneumoniae subsp. pneumoniae strain DD02357

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag M0537_RS26855 Protein ID WP_004026354.1
Coordinates 103384..103854 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag M0537_RS26860 Protein ID WP_004026357.1
Coordinates 103851..104294 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0537_RS26830 (M0537_26795) 98796..99194 - 399 WP_004212796.1 H-NS family nucleoid-associated regulatory protein -
M0537_RS26835 (M0537_26800) 99531..100025 - 495 WP_004212794.1 thermonuclease family protein -
M0537_RS26840 (M0537_26805) 100203..100469 + 267 WP_223175074.1 DUF1173 family protein -
M0537_RS26845 (M0537_26810) 100502..101152 + 651 WP_068893702.1 DUF1173 family protein -
M0537_RS26855 (M0537_26820) 103384..103854 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
M0537_RS26860 (M0537_26825) 103851..104294 - 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
M0537_RS26865 (M0537_26830) 104395..104898 - 504 Protein_114 DUF4113 domain-containing protein -
M0537_RS26870 (M0537_26835) 104996..105217 - 222 WP_004213643.1 DUF2188 domain-containing protein -
M0537_RS26875 (M0537_26840) 105392..105517 - 126 Protein_116 Fe3+-citrate ABC transporter substrate-binding protein -
M0537_RS26880 (M0537_26845) 105592..107718 - 2127 WP_004213640.1 TonB-dependent Fe(3+) dicitrate receptor FecA -
M0537_RS26885 (M0537_26850) 107805..108758 - 954 Protein_118 fec operon regulator FecR -
M0537_RS26890 (M0537_26855) 108755..109276 - 522 WP_004213635.1 ferric citrate uptake sigma factor FecI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroB / iroC / iroD / iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA 1..229626 229626
- flank IS/Tn - - 102538..103041 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T242932 WP_004026354.1 NZ_CP096235:c103854-103384 [Klebsiella pneumoniae subsp. pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

>T242932 NZ_OW968111:2671267-2671374 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT242932 WP_004026357.1 NZ_CP096235:c104294-103851 [Klebsiella pneumoniae subsp. pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp

>AT242932 NZ_OW968111:c2671220-2671154 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References